ArticleCureus2025
Association of Gene Polymorphism of Matrix Metalloproteinase-9 With Chronic Periodontitis: A Cross-Sectional Survey in a South Indian Population.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsMatrix metalloproteinases (MMPs) have an important role in the remodeling and destruction of periodontal tissues. Genetic polymorphisms of MMPs have been investigated as probable candidate gene markers, potentially associated with the susceptibility, severity, and clinical outcome of periodontal disease. This cross-sectional study was designed to determine whether there is any association between the single-nucleotide polymorphism (SNP) of the
methodsA total of 170 subjects participated in the study, which included 80 subjects with chronic generalized periodontitis and 90 controls, who belonged to the South Indian (Kerala) ethnicity. The samples were genotyped by using PCR followed by sequencing/RFLP. The genotype and allele frequency of the
resultsIn our study population, there was no statistically significant difference in the genotype frequencies of the
conclusionWithin the limitations of sample size and selection, results of the present study suggest a possible lack of association between the
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