ReviewCureus2025
The Effects of Hypertension Treatment on Heart Rate Variability: A Scoping Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Coumarins in hypertension management: from vascular signaling pathways to clinical perspectives.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Predicting the Risk of Cardiovascular Diseases in the Elderly Based on Clinical Data and Heart Rate Variability Using Machine Learning.Journal of clinical medicine · 2026Article
- Associations of Poincaré Plot-Derived Parameters with Heart Rate Variability and Autonomic Reflex Testing in a Real-World Clinical Population.Diagnostics (Basel, Switzerland) · 2026Article
- Autonomic Nervous System Dysfunction in Diabetic Patients After Myocardial Infarction: Prognostic Role of the Valsalva Maneuver.Medicina (Kaunas, Lithuania) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This scoping review systematically gathered and synthesized evidence on the effects of antihypertensives on heart rate variability (HRV) in patients with hypertension (HTN). Antihypertensives are the cornerstone of blood pressure (BP) control, yet their influence on HRV, a marker of autonomic function and a predictor of cardiovascular outcomes, remains incompletely understood. A scoping review approach was selected to map the breadth of available evidence and identify knowledge gaps, focusing on randomized controlled trials to maximize internal validity. A scoping review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping review (PRISMA-ScR) guidelines. EMBASE, Ovid Medline, Web of Science, and CINAHL were searched for randomized controlled trials published between 1995 and 2021. Only English-language, peer-reviewed studies were included; gray literature was excluded. Twenty-nine trials involving 2,230 participants were included, though designs were heterogeneous in duration and population characteristics. HRV was variably assessed using time-domain, frequency-domain, and nonlinear measures. Beta-blockers and non-dihydropyridine calcium channel blockers consistently enhanced parasympathetic activity and improved HRV. Angiotensin receptor blockers improved HRV in patients with concomitant metabolic syndrome, whereas alpha-1 antagonists showed limited but positive effects. Angiotensin-converting enzyme inhibitors and thiazide diuretics demonstrated minimal impact on HRV. No formal risk of bias assessment was performed, consistent with scoping methodology. The effect of antihypertensive therapy on HRV is drug-class dependent, with beta-blockers and non-dihydropyridine calcium channel blockers showing the most consistent benefits. Evidence-related gaps remain, particularly regarding under-studied drug classes, heterogeneous HRV measurement methods, and limited trial size. These findings highlight the potential role of HRV as a therapeutic consideration in HTN management and underscore the need for targeted research on under-studied drug classes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.