ArticleJournal of medical biochemistry2025
Prognostic value of serum CRP, IgM and IgA levels in children with Mycoplasma pneumoniae and pleural effusion.
Article in Journal of medical biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Immune dysregulation and pathogen prevalence in Mycoplasma pneumoniae pneumonia: a retrospective insight in children.Frontiers in pediatrics · 2026Article
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Abstract
Background: Mycoplasma pneumoniae pneumonia (MPP) is a common cause of community-acquired pneumonia in children, with pleural effusion (PE) as a recognised but challenging complication. Identifying reliable biomarkers to predict PE in MPP is crucial for timely intervention. This study aims to evaluate the prognostic value of serum C-reactive protein (CRP), Immunoglobulin M (IgM), and Immunoglobulin A (IgA) levels in children with MPP and PE. Methods: A retrospective study was conducted on 200 pediatric patients diagnosed with MPP between January 2021 and December 2023. Patients were divided into two groups: MPP with PE (n=100) and MPP without PE (n=100). Serum CRP , IgM, and IgA levels were measured, and their associations with PE were analysed using logistic regression models. Results: The MPP with PE group had significantly higher CRP (30.22±24.01 mg/L vs 9.90±7.01 mg/L, P<0.001) and IgM (167.39±85.68 mg/dL vs 130.48±77.65 mg/dL, P=0.002) levels compared to the MPP without PE group. In contrast, IgA levels were significantly lower in the PE group (164.50±87.22 mg/dL vs. 195.51±79.93 mg/dL, P=0.009). Multivariate logistic regression analysis revealed that elevated CRP (OR=1.255, 95% CI: 1.132-1.391, P<0.001) and IgM (OR=1.795, 95% CI: 1.777-4.867, P=0.001) were independent risk factors for PE, while higher IgA levels were protective (OR=0.281, 95% CI: 0.131-0.602, P=0.001). Conclusions: Serum CRP and IgM levels are potential predictors of pleural effusion in children with MPP , while elevated IgA levels may indicate a lower risk. These biomarkers could aid in early risk stratification and guide clinical management to improve outcomes.
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