ArticleiScience2025
Multiregional single-cell transcriptomics reveals an association between partial EMT and immunosuppressive states in oral squamous cell carcinoma.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Decoding epithelial-mesenchymal transitions with multi-omics.Nature reviews. Genetics · 2026Review
- PLAU accelerates extracellular matrix remodeling through partial epithelial-mesenchymal transition in head and neck squamous cell carcinoma.Translational cancer research · 2026Article
- A unified single-cell atlas of HNSCC: Toward characterizing HPV- and sex-associated TME variability.iScience · 2026Article
- Chemokine-Like Receptor 1 Knockdown Suppresses Oral Squamous Cell Carcinoma Progression by Reducing Oxidative Phosphorylation.International dental journal · 2026Article
- Review
- ROS-Mediated Apoptosis Induction by a Cationic Pyridoxal Benzoylhydrazone Copper Complex in Oral Cancer Cells.ACS omega · 2026Article
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral squamous cell carcinoma (OSCC) is highly heterogeneous and metastatic, and the mechanisms driving OSCC development, progression, and metastasis remain elusive. Here, we performed single-cell RNA sequencing on 231,442 cells obtained from the tumor core (TC), tumor periphery (TP), adjacent surrounding tissue (ST), and metastatic lymph node (mLN) samples of 10 patients with human papillomavirus (HPV)-negative OSCC. TP and TC showed no major immune cell phenotype differences. Interestingly, partial EMT (p-EMT) cells showed significant activation of glycolysis and hypoxia signatures, serving as potential biomarkers for clinical outcomes. Moreover, p-EMT scores of epithelial cells positively correlated with M2 scores of tumor-associated macrophages, while the proportion of p-EMT at TP was negatively associated with that of
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