Evidence map›Paper›PMID 41054542›Full record

ArticleiScience2025

The noncoding circular RNA

Kyle R Jenks, Ying Cai, Marvin Eduarte Nayan, Katya Tsimring, Keji Li, José C Zepeda, Gregg R Heller, Chloe Delepine, Jennifer Shih, Shiyang Yuan and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Circular RNAScience advances · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Kyle R JenksDepartment of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Ying CaiSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Marvin Eduarte NayanDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Katya TsimringDepartment of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Keji LiDepartment of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
José C ZepedaDepartment of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Gregg R HellerDepartment of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Chloe DelepineDepartment of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jennifer ShihDepartment of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Shiyang YuanSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Yao ZhuSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Ye WangDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Yangyang DuanDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Amy K Y FuDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Taeyun KuGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Dae Hee YunDepartment of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Kwanghun ChungDepartment of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Nikolaos MelliosCircular Genomics Inc, San Diego, CA 92121, USA.
Mriganka SurDepartment of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jacque Pak Kan IpSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.

Funding

MicroRNA mechanisms of Rett SyndromeR01MH085802 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SUR, MRIGANKA · 2010 to 2025
$6.2M
Astrocyte-neuron interactions in visual cortex circuitsR01EY028219 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SUR, MRIGANKA · 2018 to 2021
$2.3M
Visual cortex circuits mediating arousal and visual discriminationF32EY032756 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JENKS, KYLE ROBERT · 2022 to 2024
$221k
Alignment of visual features in binocular cortical circuits through experience dependent synaptic plasticityF31EY033649 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TSIMRING, KATHERINE RACHEL · 2022 to 2024
$79k
NEI NIH HHS F31 EY033649NEI NIH HHS F32 EY032756NEI NIH HHS R01 EY028219NIMH NIH HHS R01 MH085802
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are closed-loop, single-stranded RNAs particularly enriched in the brain. Despite this enrichment, and evidence showing that synaptic development and plasticity alter their expression

Indexed as

Developmental biologyGeneticsMolecular biologyNeuroscience

Identifiers

PMID41054542
PMCPMC12496186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.