Evidence map›Paper›PMID 41054519›Full record

ArticleiScience2025

Phosphorylation of presynaptic PLPPR3 controls synaptic vesicle release.

Cristina Kroon, Shannon Bareesel, Gerard Aguilar Perez, Domonkos Nagy-Herczeg, Dimitra Ranti, Vasiliki Syropoulou, Sandra Coveney, Marieluise Kirchner, Niclas Gimber, Willem Bintig and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Cristina KroonInstitute of Molecular Biology and Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Shannon BareeselInstitute of Molecular Biology and Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Gerard Aguilar PerezLaboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.
Domonkos Nagy-HerczegInstitute of Molecular Biology and Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Dimitra RantiInstitute of Molecular Biology and Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Vasiliki SyropoulouInstitute of Molecular Biology and Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Sandra CoveneyCell Signaling Technology, 3 Trask Lane, Danvers, MA 01923, USA.
Marieluise KirchnerCore Unit Proteomics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Niclas GimberAdvanced Medical Bioimaging Core Facility, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Willem BintigInstitute of Molecular Biology and Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Annika BrosigInstitute of Molecular Biology and Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Georg BrauneInstitute of Molecular Biology and Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Kathrin Textoris-TaubeCore Facility High Throughput Mass Spectrometry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Timothy A ZolnikInstitute of Molecular Biology and Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Philipp MertinsCore Unit Proteomics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Jan SchmoranzerAdvanced Medical Bioimaging Core Facility, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Dragomir MilovanovicLaboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.
George LeondaritisDepartment of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Britta J EickholtInstitute of Molecular Biology and Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phospholipid-phosphatase-related protein 3 (PLPPR3) belongs to a family of transmembrane proteins highly expressed in the nervous system where it regulates critical axonal growth processes during guidance, filopodia formation, and branching. However, little is known regarding its role in synapses and the signaling events regulating PLPPR3 function. Here, we identify 26 high-confidence phosphorylation sites in the intracellular domain of PLPPR3 using mass spectrometry. Biochemical characterization established one of these-S351-as a

Indexed as

biochemistrycell biologyneuroscience

Identifiers

PMID41054519
PMCPMC12496174

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.