Evidence map›Paper›PMID 41054506›Full record

ArticleiScience2025

SARS-CoV-2 infection drives local inflammation of the intestinal epithelium in immunocompromised patients with cancer.

Emil Lou, Christine Luo, Katherine Ladner, Allison Makovec, Phillip Wong, Jeremy Chacon, Eamon Toye, Ella Boytim, Emily Gammon Hawkins, Anthony Patregnani and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Emil LouDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Christine LuoDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Katherine LadnerDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Allison MakovecDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Phillip WongDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Jeremy ChaconDepartment of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Eamon ToyePerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ella BoytimDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Emily Gammon HawkinsDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Anthony PatregnaniDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Emily JohnDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Sanyukta PadmanabhanDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Akshat SarkariDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Alison WongDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Julia StuartDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Andrew C NelsonDepartment of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Brian BettsRoswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA.
Eliseo EugeninDepartment of Neurobiology, John Sealy School of Medicine, The University of Texas Medical Branch, Building 17, Fifth Floor, Galveston, TX 77555-0620, USA.
Justin HwangDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer patients undergoing transplantation-based treatments can develop graft-versus-host disease (GVHD), an inflammatory condition that increases mortality risk. In this study, we analyzed three cancer patients with severe inflammatory disorders following SARS-CoV-2 infection using high-resolution microscopy and spatial transcriptomics on pre- and post-infection gastrointestinal (GI) biopsies. We found that up to 49 days after infection, the duodenal epithelium retained COVID viral elements, showed increased expression of viral receptors, inflammatory genes, and interferon activity, and exhibited tissue scarring. Notably, SERPINA1 was a persistent marker of infection and inflammation, also present in ∼600 GI tumor samples, suggesting its role as a broader inflammation marker. These findings indicate that the GI epithelium can serve as a long-term COVID reservoir, potentially driving inflammatory syndromes similar to GVHD. This persistent viral presence may pose additional risks for cancer patients undergoing transplantation, highlighting the need for further investigation into post-COVID inflammatory complications in cancer patients.

Indexed as

CellImmunity

Identifiers

PMID41054506
PMCPMC12496208

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.