Evidence map›Paper›PMID 41054474›Full record

ArticleJournal of maxillofacial and oral surgery2025

Chronic Viral Infections and Development of Vascular Malformations/Tumors of Head and Neck: Is There a Correlation?

Stefania Troise, Federica Calabria, Giulia Togo, Andrea Bagnato, Rosa Maria Di Crescenzo, Vincenzo Abbate, Giovanni Dell'Aversana Orabona

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of maxillofacial and oral surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stefania TroiseMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Pansini 5, 80131 Naples, Italy.ORCID 0000-0001-8421-0328
Federica CalabriaMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Pansini 5, 80131 Naples, Italy.
Giulia TogoMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Pansini 5, 80131 Naples, Italy.
Andrea BagnatoMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Pansini 5, 80131 Naples, Italy.
Rosa Maria Di CrescenzoPathology Section, Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.
Vincenzo AbbateMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Pansini 5, 80131 Naples, Italy.
Giovanni Dell'Aversana OrabonaMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Pansini 5, 80131 Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Angiogenesis is the process of new vessels formation. Vascular endothelial growth factor (VEGF) is the most involved growth factor in endothelial cell proliferation. Many viruses are implicated in this process, directly through membrane receptors or indirectly by stimulating VEGF production. In particular, hepatitis B virus (HBV) can stimulate proliferation of endothelial cells, contributing to the development of vascular malformations and tumors, benign as hemangiomas or malignant as hepatocarcinoma or cholangiocarcinoma. Objective: Starting from these assumptions, the authors of this observation paper questioned the possibility that chronic HBV infection could determine vascular malformations/tumors also in other areas, in particular head and neck. Case Description: To answer this question, a case of a 52-year-old woman with chronic HBV infection, who developed a vascular malformation of the upper lip, was described. Conclusion: This hypothesis of correlation between chronic viral infections, with a blood viral load 0, and vascular malformations/tumors can lay the foundations for carrying out molecular studies.

Indexed as

AngiogenesisChronic viral infectionsHead and neckHepatitis B virusUpper lipVascular malformation

Identifiers

PMID41054474
PMCPMC12496338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.