ArticleEClinicalMedicine2025
Streptococcal endocarditis: a meta-analysis of species dependant risk.
Article in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Choice of antimicrobial therapy for infective endocarditis caused by viridans streptococci: an international practice survey.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Infective Endocarditis Mimicking Reactive Arthritis: A Diagnostic Detour.JACC. Case reports · 2026Article
- Eustachian and Aortic Valve Endocarditis: A Rare Case of Concomitant Right- and Left-Sided Endocarditis.Cureus · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Streptococcal infective endocarditis (IE) is a devastating disease. In international guidance, the risk of IE from streptococci is considered the same regardless of species (excluding Methods: We first conducted a scoping review for publications that reported cases of streptococcal bacteraemia differentiated by species and estimated the risk of IE between 1994 and October 2024. Then we supplemented this data with our own laboratory data from four large hospitals. We meta-analysed the risk of IE. Two sensitivity analyses were performed to deal with one manuscript which excluded cultures considered as contaminants: first, by excluding that publication, and second by adjusting for blood culture contamination using our local estimated contamination rates. Findings: Four studies met inclusion criteria comprising a total of 14,183 isolates with 1028 endocarditis cases (7.25% absolute risk of IE). The highest risk species were: Interpretation: The 'small five' streptococci: Funding: FH was funded by the NIHR Clinical Lectureship Scheme. TL has salary support from Fonds de Recherche Québec - Santé. PW is funded by a Medical Research Council grant MR/T005408/1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.