ArticleJournal of the American Chemical Society2025
Stapling of β-Glucans Increases Antibody Binding.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Using Synthetic Glycans to Investigate Anti-Glycan Antibodies and Explore Their Medical Potential.Angewandte Chemie (International ed. in English) · 2026Review
- Solid-Phase Glycolipid Synthesis Expedites Liposome Functionalization.Journal of the American Chemical Society · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Higher-order structures are essential for the function of biological macromolecules. Tuning the conformational space of peptides by stapling improves their pharmacological properties. The three-dimensional (3D) structures of glycans are much less well understood than those of peptides and oligonucleotides, and willful modulation of oligosaccharide structures to improve binding to proteins has not been described to date. Herein, we describe stapling of β-(1,3)-glucans to tune their conformation, aiming to mimick the naturally occurring triple helix. The stapled glycans are prepared by automated glycan assembly, followed by linker construction and ring-closure assisted by solid-phase peptide synthesis. Thereby, staples of different lengths, polarities, and topologies can be readily introduced. Molecular dynamics simulations served to evaluate the effect of stapling on the conformational space. Glycan microarray experiments revealed that stapled glycans bound significantly more tightly to monoclonal mouse and rabbit antibodies than did linear glycans. Controlling the conformational space of short oligosaccharides creates opportunities for synthetic glycans in drug and vaccine development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.