Evidence map›Paper›PMID 41053977›Full record

ReviewChemical record (New York, N.Y.)2025

A Decade of Progress: Review of the Synthesis of Dibenzo[b,f]oxepines.

Gabriel Pereira da Costa, Bruna Rafaella Schneider, Angelita Manke Barcellos, Liane Krolow Soares, Rafael Centurião Brinkerhoff, Fernanda Piecha Ludwig, Alex Fabiani Claro Flores

Abstract readReview
In one paragraph

Review in Chemical record (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gabriel Pereira da CostaNúcleo de Estudo Estrutural e Síntese de Heterociclos - NEESH, Universidade Federal do Rio Grande - FURG, Escola de Química e Alimentos - EQA, Itália Ave., km 8, Campus Carreiros, Rio Grande, 96.203-900, RS, Brazil.ORCID https://orcid.org/0000-0003-4107-9619
Bruna Rafaella SchneiderPesquisa em Síntese Orgânica Sustentável - PSOS, Universidade Federal do Rio Grande - FURG, Escola de Química e Alimentos - EQA, Itália Ave., km 8, Campus Carreiros, Rio Grande, 96.203-900, RS, Brazil.
Angelita Manke BarcellosPesquisa em Síntese Orgânica Sustentável - PSOS, Universidade Federal do Rio Grande - FURG, Escola de Química e Alimentos - EQA, Itália Ave., km 8, Campus Carreiros, Rio Grande, 96.203-900, RS, Brazil.
Liane Krolow SoaresPesquisa em Síntese Orgânica Sustentável - PSOS, Universidade Federal do Rio Grande - FURG, Escola de Química e Alimentos - EQA, Itália Ave., km 8, Campus Carreiros, Rio Grande, 96.203-900, RS, Brazil.
Rafael Centurião BrinkerhoffPesquisa em Síntese Orgânica Sustentável - PSOS, Universidade Federal do Rio Grande - FURG, Escola de Química e Alimentos - EQA, Itália Ave., km 8, Campus Carreiros, Rio Grande, 96.203-900, RS, Brazil.
Fernanda Piecha LudwigNúcleo de Estudo Estrutural e Síntese de Heterociclos - NEESH, Universidade Federal do Rio Grande - FURG, Escola de Química e Alimentos - EQA, Itália Ave., km 8, Campus Carreiros, Rio Grande, 96.203-900, RS, Brazil.
Alex Fabiani Claro FloresNúcleo de Estudo Estrutural e Síntese de Heterociclos - NEESH, Universidade Federal do Rio Grande - FURG, Escola de Química e Alimentos - EQA, Itália Ave., km 8, Campus Carreiros, Rio Grande, 96.203-900, RS, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 310635/2022-5Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 23/2551-0000766-5Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul PDJ 23/2551-0001921-3
6 · The paper itself

Abstract

This review article highlights the significant advances in the synthesis of dibenzo[b,f]oxepines over the past decade. Dibenzo[b,f]oxepines, important heterocyclic compounds, have attracted increasing interest due to their wide-ranging applications in medicinal chemistry and materials applications. The review addresses traditional approaches and recent developments, highlighting efficient synthetic strategies such as cross-coupling reactions, intramolecular cyclizations, and molecular diversification strategies. Additionally, the efficiency, selectivity, and sustainability of these methods are discussed. Emerging trends and future challenges in the synthesis of dibenzo[b,f]oxepines are also explored, including the search for more sustainable methods, the expansion of structural diversity, and the optimizing reaction conditions. This review provides a comprehensive overview of recent advances in this field, providing valuable insights for researchers aiming to develop novel synthetic strategies and applications for dibenzo[b,f]oxepines.

Indexed as

dibenzo[b,f]oxepinesO‐heterocyclesoxepine ring constructionpharmaceutical applicationsseven‐membered heterocycles

Identifiers

PMID41053977
PMCPMC12521962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.