ArticlePhotochemistry and photobiology
Exploring natural sunscreens: UVB protection and antioxidant properties in gadusol-rich fish roes extracts.
Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Metabolic engineering ofSynthetic and systems biotechnology · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
The search for natural alternatives to synthetic sunscreens has driven interest in marine compounds with antioxidant and UV-protective properties. The present study expands our understanding of the potential of gadusol by evaluating the photochemoprotective and antioxidant effects of extracts from an underexploited marine by-product: the roes of yellowtail amberjack fish (Seriola lalandi). UVB-mediated responses were studied in vitro and in vivo using HaCaT keratinocytes and Caenorhabditis elegans worms, respectively. Additionally, several antioxidant assays were conducted to evaluate the antioxidant capacity and thermal stability over time. We also tested the docking binding of gadusol to the Nrf2-binding domain of Keap1 to better understand its potential chemoprotective role. Overall, the gadusol-containing extracts exhibited remarkable stability over time, offering effective protection against UVB radiation in both in vitro and in vivo models. This information contributes to a better characterization of the functional role of gadusol in crude extracts and its relevance for the design of innovative applications in various pharmaceutical and cosmetic industries.
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