Evidence map›Paper›PMID 41053941›Full record

ArticleAdvanced healthcare materials2026

Formulating Smart All-in-One Chitosan Hydrogel for High Performance Wound Dressing.

Chia-Chi Lin, Andi Magattang Gafur Muchlis, Ren-Jei Chung, Ssu Yu Huang, Michal Martinka, Syang-Peng Rwei, Aivaras Kareiva, Jen-Chang Yang, Chun Che Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chia-Chi LinInstitute of Organic and Polymeric Materials, National Taipei University of Technology, No. 1, Section 3, Zhongxiao E. Rd, Daan District, Taipei, 10608, Taiwan.
Andi Magattang Gafur MuchlisInstitute of Organic and Polymeric Materials, National Taipei University of Technology, No. 1, Section 3, Zhongxiao E. Rd, Daan District, Taipei, 10608, Taiwan.ORCID 0009-0005-5615-2489
Ren-Jei ChungDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Zhongxiao E. Rd, Daan District, Taipei, 10608, Taiwan.
Ssu Yu HuangIndustrial Technology Research Institute, No. 321, Sec. 2, Guangfu Rd., East Dist., Hsinchu City, 300044, Taiwan.
Michal MartinkaDepartment of Clothing Technology, Technical University of Liberec, Studentská 1402/2, Liberec 1, Liberec, 461 17, Czech Republic.
Syang-Peng RweiInstitute of Organic and Polymeric Materials, National Taipei University of Technology, No. 1, Section 3, Zhongxiao E. Rd, Daan District, Taipei, 10608, Taiwan.
Aivaras KareivaInstitute of Chemistry, Vilnius University, 3 Universiteto St., LT-01513, Vilnius, 03225, Lithuania.
Jen-Chang YangGraduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, No.301, Yuantong Rd., Zhonghe Dist., New Taipei City, 235, Taiwan.
Chun Che LinInstitute of Organic and Polymeric Materials, National Taipei University of Technology, No. 1, Section 3, Zhongxiao E. Rd, Daan District, Taipei, 10608, Taiwan.ORCID 0000-0001-9261-2482

Funding

Joint Research Program Funding Sponsorship by University System of TaipeiNational Science and Technology Council NSTC 114-2113-M-027-001National Science and Technology Council NSTC 114-2628-E-027-006-MY3
6 · The paper itself

Abstract

The poor mechanical and film formation properties of chitosan hydrogel limit its application as a wound dressing. To solve this shortcoming, chitosan-graft-poly(N-isopropyl acrylamide) (PNIPAAm) and crosslinked with polyvinyl alcohol/polyvinyl pyrollidone (PVA/PVP) blend polymer is designed to form the thermosensitive hydrogel. After that, silver nanoparticles (AgNPs), synthesized by the co-reduction method, are added into the chitosan hydrogel network to provide better antibacterial ability. When the temperature is above 32 °C, the hydrogel showed a decrease in particle size and transmittance, which proved that it is a thermal responsive material. Chitosan hydrogels are evaluated for their thermal properties, mechanical properties, swelling effects, antibacterial properties, and wound healing ability in rats. The results show that the hydrogel has a large number of intermolecular and intramolecular hydrogen bonds and a porous 3D network structure. The swelling ratio is 358.86 ± 23.56% and the degradation ratio is 86.02 ± 2.82% at 21 days. It also has excellent antibacterial properties against Escherichia coli and a much faster wound recovery ability. Therefore, a chitosan hydrogel with excellent physical properties is formulated in this study and has great potential as a smart all-in-one wound dressing for accelerating wound healing.

Indexed as

BandagesChitosanHydrogelsWound HealingAcrylic ResinsAnimalsAnti-Bacterial AgentsEscherichia coliMaleMetal NanoparticlesPolyvinyl AlcoholRatsRats, Sprague-DawleySilverAcrylic ResinsAnti-Bacterial AgentsChitosanHydrogelspoly-N-isopropylacrylamidePolyvinyl AlcoholSilverantibacterialchitosan hydrogelhydrogen bondthermosensitivewound dressing

Identifiers

PMID41053941
PMCPMC12836463

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.