Evidence map›Paper›PMID 41053909›Full record

ArticleGenome biology2025

A nucleoporin-associated signaling cascade controls plant immunity via histone modification.

Leiwen Pan, Shun Peng, Yuehui Zhang, Huan Chang, Yi Yang, Dongbei Guo, Yuan Guo, Yakun Han, Ting Mao, Yuchen Huang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A transposon insertion in the promoter ofHorticulture research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Leiwen Pan *Shanghai Engineering Research Center of Plant Germplasm Resources, Shanghai Collaborative Innovation Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Shun Peng *Shanghai Engineering Research Center of Plant Germplasm Resources, Shanghai Collaborative Innovation Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Yuehui Zhang *Shanghai Engineering Research Center of Plant Germplasm Resources, Shanghai Collaborative Innovation Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Huan Chang *Shanghai Engineering Research Center of Plant Germplasm Resources, Shanghai Collaborative Innovation Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Yi YangShanghai Engineering Research Center of Plant Germplasm Resources, Shanghai Collaborative Innovation Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Dongbei GuoShanghai Engineering Research Center of Plant Germplasm Resources, Shanghai Collaborative Innovation Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Yuan GuoShanghai Engineering Research Center of Plant Germplasm Resources, Shanghai Collaborative Innovation Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Yakun HanShanghai Engineering Research Center of Plant Germplasm Resources, Shanghai Collaborative Innovation Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Ting MaoShanghai Engineering Research Center of Plant Germplasm Resources, Shanghai Collaborative Innovation Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Yuchen HuangShanghai Engineering Research Center of Plant Germplasm Resources, Shanghai Collaborative Innovation Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
Shui WangShanghai Engineering Research Center of Plant Germplasm Resources, Shanghai Collaborative Innovation Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China. shuiwang@shnu.edu.cn.

Funding

National Natural Science Foundation of China 32270290
6 · The paper itself

Abstract

backgroundPlants undergo massive transcriptional reprogramming upon pathogen infection. The transcription factors SAR DEFICIENT1 (SARD1) and CAM-BINDING PROTEIN 60-LIKE G (CBP60g) are master regulators of this process. However, the regulation of SARD1 and CBP60g transcription remains unclear.

resultsWe discover a signaling complex centered on the plant-specific nucleoporins CONSTITUTIVE EXPRESSION OF PR GENES 5 (CPR5) and GUANYLATE-BINDING PROTEIN-LIKE GTPASE 3 (GBPL3), which critically regulates SARD1 and CBP60g transcription. We establish that the RNA processing complexes NineTeen Complex (NTC) and CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR (CPSF) act downstream of CPR5 to activate immunity. A genetic screen identifies GBPL3 and key histone modification complex components as suppressors of the autoimmune phenotype in cpr5 mutants, functioning downstream of NTC/CPSF. Transcriptomic and genetic analyses demonstrate that SARD1 and CBP60g are fully responsible for autoimmune activation in cpr5. Crucially, GBPL3 and the histone modifiers physically interact, bind directly to the SARD1 and CBP60g loci, and repress their expression. Pathogen infection substantially reduces this binding. Consistently, the active histone mark H3K4me3 at SARD1 and CBP60g is modulated by the CPR5-NTC/CPSF-GBPL3/histone modifiers cascade and accumulates significantly upon pathogen infection.

conclusionsOur findings reveal a CPR5-NTC/CPSF-GBPL3/histone modifiers signaling cascade that controls the transcription of the SARD1 and CBP60g via histone modification, thereby modulating the transcriptional reprogramming during plant immune responses.

Indexed as

ArabidopsisArabidopsis ProteinsHistone CodeNuclear Pore Complex ProteinsPlant ImmunitySignal TransductionGene Expression Regulation, PlantHistonesRNA-Binding ProteinsArabidopsis ProteinsHistonesNuclear Pore Complex ProteinsRNA-Binding ProteinsSARD1 protein, ArabidopsisCBP60CPR5GBPL3Guanylate-binding proteinHistone modificationNineTeen ComplexNuclear pore complexPlant immunity

Identifiers

PMID41053909
PMCPMC12498470

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.