Evidence map›Paper›PMID 41053896›Full record

Trial reportHead & face medicine2025

Clinical efficacy of vitamin D combined with conventional therapy for sudden sensorineural hearing loss in patients with vitamin D deficiency: a randomized controlled trial.

Xueliang Shen, Meihua Yang, Jiapeng Tian, Lina Xie, Ningyu Feng, Ruixia Ma

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Head & face medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pathophysiologic phenotyping of idiopathic sudden sensorineural hearing loss: toward precision management.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xueliang Shen *Second Clinical Medical College of Ningxia Medical University, No.2 Liqun West Road, Yinchuan, 750001, Ningxia, China.
Meihua Yang *Second Clinical Medical College of Ningxia Medical University, No.2 Liqun West Road, Yinchuan, 750001, Ningxia, China.
Jiapeng TianSecond Clinical Medical College of Ningxia Medical University, No.2 Liqun West Road, Yinchuan, 750001, Ningxia, China.
Lina XieSecond Clinical Medical College of Ningxia Medical University, No.2 Liqun West Road, Yinchuan, 750001, Ningxia, China.
Ningyu FengSecond Clinical Medical College of Ningxia Medical University, No.2 Liqun West Road, Yinchuan, 750001, Ningxia, China.
Ruixia MaSecond Clinical Medical College of Ningxia Medical University, No.2 Liqun West Road, Yinchuan, 750001, Ningxia, China. maruixia4368@126.com.

Funding

Ningxia Natural Science Foundation 2023AACO3871
6 · The paper itself

Abstract

objectiveThis study aimed to evaluate whether adjunctive vitamin D supplementation enhances the efficacy of conventional therapy in treating sudden sensorineural hearing loss (SSNHL) in patients with vitamin D deficiency, and to assess both short-term and long-term clinical outcomes.

methodsIn this prospective randomized controlled trial, 101 SSNHL inpatients with vitamin D deficiency (serum 25-hydroxyvitamin D < 75 nmol/L) were enrolled at Yinchuan First People's Hospital (January-December 2024). Participants were randomized into a control group (n = 51, receiving conventional therapy: methylprednisolone and ginkgo biloba extract) and an experimental group (n = 50, conventional therapy + oral vitamin D3 [1500-2000 IU/day] for 10 days). Hearing and tinnitus outcomes were assessed via pure tone audiometry (PTA) and the Tinnitus Handicap Inventory (THI) at baseline, 10 days, and 3 months.

resultsBaseline characteristics were comparable between groups (all P > 0.05). At 10 days, the experimental group demonstrated significantly higher total effective rates for hearing recovery (82.0% vs. 52.9%, P < 0.001) and tinnitus improvement (83.3% vs. 71.1%, P = 0.007) compared to the control group. Mean PTA improvement was 29.3 dB HL vs. 14.2 dB HL (P < 0.001). At 3 months, the experimental group maintained significantly better outcomes, with a mean PTA improvement of 25.1 dB HL versus 12.5 dB HL in the control group (P < 0.001) and a greater reduction in THI scores (27.5 vs. 13.9, P < 0.001). The total effective rate for hearing remained superior in the experimental group (76.0% vs. 47.1%, P = 0.002).

conclusionVitamin D supplementation combined with conventional therapy significantly improves both short-term and sustained long-term hearing and tinnitus outcomes in SSNHL patients with vitamin D deficiency. These findings support its role as a safe and effective adjuvant treatment, warranting further validation through multicenter trials.

Indexed as

CholecalciferolHearing Loss, SensorineuralHearing Loss, SuddenMethylprednisoloneVitamin DVitamin D DeficiencyVitaminsAdultAudiometry, Pure-ToneDietary SupplementsFemaleGinkgo bilobaGinkgo ExtractHumansMaleMiddle AgedCholecalciferolGinkgo biloba extractGinkgo ExtractMethylprednisolonePlant ExtractsVitamin DVitaminsHearing outcomeLong-term efficacyRandomized controlled trialSudden sensorineural hearing lossTinnitus outcomeVitamin d

Identifiers

PMID41053896
PMCPMC12502239

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.