ArticleBMC research notes2025
Discovery of small molecules with anthelmintic potential in the Medicines for Malaria Venture's COVID and Global Health Priority Boxes using an infrared-based assay for Caenorhabditis elegans motility.
Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A practical miracidial motility assay for assessing Fasciola hepatica sensitivity to compounds in vitro.International journal for parasitology. Drugs and drug resistance · 2026Article
- Discovery of small molecules with anthelmintic potential in the Medicines for Malaria Venture's COVID and Global Health Priority Boxes using an infrared-based assay for Caenorhabditis elegans motility.BMC research notes · 2025Article
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Authors and funding
3 authors.
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Abstract
backgroundParasitic nematodes are a public health problem globally, and an economic burden on animal and plant agricultural industries. With their ability to generate drug resistance, new anthelmintic compounds must be constantly sourced.
methodsUsing the free-living nematode, Caenorhabditis elegans, in an infrared-based motility assay, we screened 400 compounds from two open-source, small-molecule collections distributed by the Medicines for Malaria Venture, namely, the COVID Box and Global Health Priority Box. The screening assay was first validated for worm number, DMSO concentration and final volume.
resultsPrimary and secondary (time- and concentration-dependent) screens of both boxes, identified twelve compounds as hits; nine of which are known anthelmintics. Three additional bioactives, flufenerim, flucofuron and indomethacin were identified with EC
conclusionsA C. elegans motility assay was optimized and used to screen two recently-released, small molecule libraries. Flufenerim, flucofuron and/or indomethacin might serve as starting points for the development of new anthelmintics.
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