ArticleBMC chemistry2025
Synthesis, characterization, biological and in-silico evaluation of cuminaldehyde derivatives.
Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cuminum cyminum L. is a versatile spice belonging to the family Apiaceae. It exhibits numerous culinary, traditional, and pharmacological attributes. All therapeutic effectiveness of C. cyminum is rendered by its active phytoconstituents. Cuminaldehyde is considered as the major phytocompounds of C. cyminum responsible for the plant's diverse health attributes. Therefore, in the present study, it was hypothesized that cuminaldehyde derivatives exhibited better pharmacological potential than cuminaldehyde. Therefore, cuminaldehyde derivatives were synthesized, characterized and assessed for their antimicrobial, antioxidant and cytotoxic activities. Cumin essential oil (E.O.B) was also extracted from cumin seeds via the Clevenger apparatus, characterized by GC-MS and pharmacologically compared with newly synthesized cuminaldehyde derivatives (NS-1B to NS-10B). Results revealed that higher antibacterial activity was observed in compounds, E.O.B (ZI
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