ArticleCardiovascular diabetology2025
Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident stroke in middle-aged and older Chinese adults: a longitudinal analysis based on CHARLS.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- The C-Reactive Protein-Triglyceride-Glucose Index and Functional Outcomes in Acute Ischemic Stroke Patients Following Endovascular Thrombectomy.Brain and behavior · 2026Article
- Correction: Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident stroke in middle-aged and older Chinese adults: a longitudinal analysis based on CHARLS.Cardiovascular diabetology · 2026Article
- Association of the combined triglyceride-glucose and frailty index with chronic kidney disease: evidence from two national cohort studies.Endocrine · 2026Article
- Sustained estimated VLDL-C exposure is associated with cardiometabolic multimorbidity and foam cell dysfunction: evidence from prospective cohorts andJournal of geriatric cardiology : JGC · 2026Article
- The relationship between C-reactive protein-triglyceride-glucose index and incident cardiometabolic multimorbidity in postmenopausal women: insights from the China Health and Retirement Longitudinal Study (CHARLS).BMC cardiovascular disorders · 2026Article
- C-reactive protein-triglyceride-glucose index and risk of incident depressive symptoms in older adults: an eight-year follow-up study from ELSA.Annals of general psychiatry · 2026Article
- Observational
- Associations of cumulative exposure and longitudinal change patterns of the triglyceride glucose-Chinese visceral adiposity index with incident cardiovascular disease in middle-aged and older adults: evidence from CHARLS.Cardiovascular diabetology · 2026Observational
- Association between insulin resistance surrogate markers and cardiovascular disease risk in individuals with subclinical metabolic disorders: a prospective cohort study based on baseline levels, cumulative exposure, and longitudinal trajectories.Cardiovascular diabetology · 2026Article
- Associations between the C-reactive protein-triglyceride-glucose index and its derived indices and the incidence and progression of cardiometabolic multimorbidity in participants with metabolic dysfunction-associated steatotic liver disease: a large-scale prospective cohort study.Cardiovascular diabetology · 2026Article
- Association of the C-reactive protein-triglyceride glucose index with new-onset myocardial infarction risk: a prospective cohort study.Scientific reports · 2026Article
- Associations of cumulative exposure and dynamic trajectories of the combined atherogenic and frailty index with incident cardiometabolic multimorbidity: a longitudinal analysis based on the China Health and Retirement Longitudinal Study (CHARLS).Cardiovascular diabetology · 2026Article
- Longitudinal trajectories of stroke risk among Chinese adults: a four-year community screening cohort study.BMC public health · 2026Article
- Association between C-reactive protein-triglyceride glucose related indices and all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome.Cardiovascular diabetology · 2026Article
- Predictive value of cholesterol, high-density lipoprotein, and glucose index-obesity-derived index for stroke: a cohort study.Lipids in health and disease · 2026Article
- Associations of the combined C-reactive protein-triglyceride glucose index and frailty index in different dimensions with incident stroke among individuals with stages 0-3 cardiovascular-kidney-metabolic syndrome.Cardiovascular diabetology · 2026Article
- Longitudinal associations of cumulative and repeated-measure patterns of insulin resistance surrogate indices with biological age acceleration and incident cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from CHARLS 2011-2020.Cardiovascular diabetology · 2026Article
- Association of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose and its modified indices with cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a longitudinal analysis based on CHARLS.Cardiovascular diabetology · 2026Observational
- Changes in the estimated glucose disposal rate and cardiometabolic multimorbidity in middle-aged and older adults.Cardiovascular diabetology · 2026Article
- Association of cumulative exposure and dynamic change patterns of metabolic syndrome score with cardiometabolic multimorbidity progression among middle-aged and older Chinese adults: a longitudinal analysis based on CHARLS.Cardiovascular diabetology. Endocrinology reports · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
backgroundThe C-Reactive Protein-Triglyceride-Glucose Index (CTI) has been proposed as a novel biomarker for insulin resistance and inflammation. However, research on the relationship between CTI changes and stroke is limited. This study aims to investigate the association between changes in CTI and stroke risk.
methodsParticipants were drawn from the China Health and Retirement Longitudinal Study (CHARLS). Stroke was defined as self-reported stroke. K-means clustering analysis was used to classify CTI changes, and cumulative CTI (cuCTI) was calculated as follows: (CTI
resultsA total of 4,364 participants were included in the study, among whom 323 (7.4%) experienced a stroke. The risk of stroke increased with higher levels of cuCTI. In the multivariable-adjusted model, Cox regression analysis showed that, compared with the lowest quartile (Q1), participants in the highest quartile (Q4) had a significantly increased risk of stroke by 103% (HR = 1.90, 95% CI: 1.30-2.78, P < 0.001). Furthermore, stroke risk increased progressively across ascending cuCTI quartiles (P for trend < 0.001). RCS analysis demonstrated a linear association between cuCTI and stroke risk (for nonlinearity, p < 0.001). K-means clustering identified three distinct trajectories of CTI variation. Participants with moderate and elevated CTI levels (HR = 1.53, 95% CI: 1.17-2.00, P = 0.001) and those with high CTI levels showing a slow increasing trend (HR = 1.75, 95% CI: 1.25-2.48, P < 0.001) had a significantly higher risk of stroke.
conclusionThis study demonstrates that both cuCTI and CTI changes are associated with stroke risk in middle-aged and older adults, particularly for those with consistently high CTI levels, which are linked to a significantly increased stroke risk. Monitoring long-term CTI changes and maintaining relatively low levels may help prevent stroke in this population.
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