Evidence map›Paper›PMID 41053763›Full record

ArticleBMC women's health2025

Association between childhood adiposity and gynecologic cancers: a mendelian randomization analysis.

Mengyue Zhu, Yuchen Zhang, Xiangxiang Bao, Haiyan Zhu, Wei Jin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Mengyue Zhu *Department of Gynecology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Yuchen Zhang *Department of Gynecology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Xiangxiang BaoDepartment of Gynecology, Weifang People's hospital, Shandong, Weifang, China.
Haiyan ZhuDepartment of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China. zhuhaiyan@51mch.com.
Wei JinDepartment of Gynecology, Huai'an Hospital affiliated to Yangzhou University (The Fifth People's Hospital of Huai'an City), Jiangsu, Huai'an, China. 13912070199@163.com.

Funding

Innovation Program of Shanghai Science and Technology Committee 20Y11914200National Natural Science Foundation of China 82272778
6 · The paper itself

Abstract

purposeThe causal relationship between childhood adiposity and gynecologic cancers remains unclear. We performed a two-sample Mendelian randomization (MR) study to elucidate the association between childhood adiposity and the risk of gynecologic cancers.

methodsThe three distinct indicators of childhood adiposity that constitute the exposures were childhood body mass index (CBMI), childhood body size at age 10 (CBS-10) and childhood obesity (COBE). In tandem, the study scrutinized the outcomes encompassing gynecologic cancers, including ovarian cancer (OC), endometrial cancer (EC), cervical cancer (CC) and their subtypes.

resultsThe results of the inverse variance weighted (IVW) method suggested that CBMI was positively associated with OC (OR = 1.219, 95% CI, 1.084-1.370, q-value = 9.45E-04), EC (OR = 1.417, 95% CI, 1.272-1.702, q-value = 2.04E-07) and some of their subgroups. There were positive association between CBS-10 and invasive mucinous ovarian cancer (IMOC) (OR = 1.923, 95% CI, 1.184-3.125, q-value = 0.008), EC (OR = 1.727, 95% CI, 1.396-2.137, q-value = 4.80E-07) and its subtypes as indicated by IVW. And it is suggested by IVW that COBE was positively associated with EC (OR = 1.088, 95% CI, 1.019-1.163, q-value = 0.012). Additionally, there was no association between CBMI, CBS-10 and COBE and the risk of CC.

conclusionsOverall, this study indicates that childhood adiposity is causally associated with ovarian and endometrial cancers at the genetic level, but childhood adiposity is not causally associated with cervical cancer.

Indexed as

AdiposityGenital Neoplasms, FemalePediatric ObesityBody Mass IndexChildEndometrial NeoplasmsFemaleHumansMendelian Randomization AnalysisOvarian NeoplasmsRisk FactorsUterine Cervical NeoplasmsCervical cancerChildhood adiposityEndometrial cancerOvarian cancerTwo-sample mendelian randomization analysis

Identifiers

PMID41053763
PMCPMC12502270

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.