Observational studyBMC cardiovascular disorders2025
Diagnostic and prognostic value of speckle tracking echocardiography for right ventricular dysfunction in sepsis: a retrospective observational study.
Observational study in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- ECMO in Refractory Septic Shock: Patient Selection, Timing and Hemodynamic Targets.Journal of clinical medicine · 2025Review
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Authors and funding
5 authors.
Funding
Abstract
backgroundRight ventricular dysfunction (RVD) is increasingly recognized as a prognostic factor in sepsis. The diagnostic accuracy and prognosis value of speckle tracking echocardiography (STE)-derived parameters such as right ventricular longitudinal strain (RVLS) and tissue motion annular displacement (RVTMAD) remain inadequately defined in critically ill patient.
methodsThis retrospective observational study included patients admitted to the intensive care unit (ICU) with sepsis or septic shock from March 2019 to November 2021. Transthoracic echocardiography was performed within 24 h of ICU admission. RVLS and RVTMAD were measured offline using STE. The diagnostic performance of these parameters for RVD was evaluated using ROC curve analysis, and their association with mortality was assessed using Cox regression models.
resultsAmong 159 enrolled patients, 57 (35.8%) were diagnosed with RVD. Patients with RVD exhibited significantly higher (less negative) RVLS (P < 0.05). RVTMADmid and RVTMAD% demonstrated the highest diagnostic accuracy for RVD, with AUROC values of 0.913 (95% CI: 0.866-0.960) and 0.917 (95% CI: 0.874-0.960), respectively. Patients with RVTMADmid < 10.95 mm or RVTMAD% < 16.70%, had higher in-hospital mortality. Right ventricular free-wall longitudinal strain (RVFWLS) ≥ - 18.85% was associated with higher in-hospital and 28-day mortality. In the Cox proportional hazards regression analysis, the SOFA score emerged as the sole independent predictor of in-hospital mortality.
conclusionRVTMAD is a simple and reproducible STE-derived parameter with excellent diagnostic performance for identifying RVD in sepsis. It may serve as a valuable complement to conventional echocardiographic measures, particularly when image quality is suboptimal.
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