Evidence map›Paper›PMID 41053550›Full record

ArticleBMC plant biology2025

Evolutionary trajectory of the NPF6.3(NRT1.1/CHL1)-centered nitrate signaling regulatory network in plant roots.

Ran Zhao, Jianyu Wang, Xin Yi, Jinpeng Wang, Peng Xu, Xueqian Duan, Hanying Wu, Yuannian Jiao

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ran ZhaoState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, Chinese Academy of Sciences, Beijing, China. zhaoran@ibcas.ac.cn.ORCID http://orcid.org/0000-0002-6261-5786
Jianyu WangState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, Chinese Academy of Sciences, Beijing, China.
Xin YiState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, Chinese Academy of Sciences, Beijing, China.
Jinpeng WangDepartment of Bioinformatics, School of Life Sciences, North China University of Science and Technology, Tangshan, China.
Peng XuState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, Chinese Academy of Sciences, Beijing, China.
Xueqian DuanState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, Chinese Academy of Sciences, Beijing, China.
Hanying WuKey Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Beijing, China.
Yuannian JiaoState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, Chinese Academy of Sciences, Beijing, China. jiaoyn@ibcas.ac.cn.ORCID http://orcid.org/0000-0002-8987-2782

Funding

National Natural Science Foundation of China 32100182Youth Innovation Promotion Association CAS 2022079
6 · The paper itself

Abstract

backgroundNitrogen not only influences plant growth and development but also participates in numerous signaling pathways. Plant evolved an efficient and sophisticated nitrate signaling regulatory network (NSRN) in roots for adapting to terrestrial environments. However, our understanding of when and how a complete NSRN was established remains limited.

resultsHere, we systematically identified the Homologous genes encoding 20 key components involved in the NPF6.3(NRT1.1/CHL1)-centered NSRN and elucidated their evolutionary histories. Further analysis of six core components (NPF6, CIPK, CPK, NLP, TCP, NRT2) revealed that most clades containing functional genes appeared at the ancestral node of seed plants. Moreover, the putatively functional clade members exhibit root-preferential expression patterns in gymnosperms. Protein interaction predictions indicate that, except for TCP, the interactions among other components were already established in gymnosperms and conserved in angiosperms. These results suggest that a relatively complete NSRN was likely formed at the ancestral node of seed plants. Meanwhile, the appearance of putatively functional clade members of non-core components at different evolutionary nodes likely contributes to the increasing complexity of NSRN.

conclusionsOur study provides better understanding of the evolutionary trajectory of the NPF6.3(NRT1.1/CHL1)-centered NSRN in land plants and the adaptive mechanisms of nitrogen utilization since plant terrestrialization.

Indexed as

Evolution, MolecularNitratesPlant ProteinsPlant RootsSignal TransductionCycadopsidaGene Expression Regulation, PlantGene Regulatory NetworksPhylogenyNitratesPlant ProteinsGene familyLand plantNitrogen transport systemOrigin and evolutionRegulatory network

Identifiers

PMID41053550
PMCPMC12502328

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