Evidence map›Paper›PMID 41053532›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Impact of vascular aging on stroke prognosis: the novel severity and arterial stiffness (SASt) score.

Nikolaos Kakaletsis, Athanase D Protogerou, Naohisa Hosomi, Tomohisa Nezu, Patrik Michel, Thevoz Guillaume, Davide Strambo, Young Seo Kim, Wonjae Sung, Konstantinos Vemmos and 13 more

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Nikolaos KakaletsisFirst Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece. kakaletsisnikos@yahoo.gr.ORCID http://orcid.org/0000-0002-5263-1803
Athanase D ProtogerouCardiovascular Prevention & Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Naohisa HosomiDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.
Tomohisa NezuDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.
Patrik MichelStroke Center and Neurology Service, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Thevoz GuillaumeStroke Center and Neurology Service, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Davide StramboStroke Center and Neurology Service, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Young Seo KimDepartment of Neurology, College of Medicine, Hanyang University, Seoul, Republic of Korea.
Wonjae SungDepartment of Neurology, College of Medicine, Hanyang University, Seoul, Republic of Korea.
Konstantinos VemmosDepartment of Clinical Therapeutics of Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Eleni KorompokiDepartment of Clinical Therapeutics of Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Maurizio AcampaStroke Unit, Department of Medical Sciences, Surgery and Neurosciences, "Santa Maria Alle Scotte" General Hospital, University of Siena, Siena, Italy.
Jukka PutaalaDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Lauri TulkkiDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Matthias HermannDepartment of Cardiology, University Heart Center Zurich, University Hospital Zurich, Zurich, Switzerland.
Protazy RejmerDepartment of Cardiology, University Heart Center Zurich, University Hospital Zurich, Zurich, Switzerland.
Philip M BathStroke Trials Unit, Mental Health & Clinical Neuroscience, University of Nottingham, Nottingham, UK.
Lisa J WoodhouseStroke Trials Unit, Mental Health & Clinical Neuroscience, University of Nottingham, Nottingham, UK.
Elpida AthanasopoulouCardiovascular Prevention & Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Haralampos MilionisDepartment of Internal Medicine, Medical School, University of Ioannina, University Hospital of Ioannina, Ioannina, Greece.
George NtaiosDepartment of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Vasilios KotsisThird Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece.
Christos SavopoulosFirst Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAssessing vascular aging to identify and categorize the residual risk of adverse outcomes in acute ischemic stroke (AIS) is important for improving AIS prognoses. This study aimed to investigate the prognostic value and correlation among three indirect measures of vascular aging derived from 24-hour blood pressure monitoring (24 h-BPM) following AIS. Furthermore, it aimed to develop a new score that includes vascular aging metrics to enhance the prognostic accuracy for stroke outcomes.

methodsA total of 2,730 AIS patients with a mean age of 72.0 ± 14.4 years who underwent 24 h-BPM were included. Three vascular aging indexes derived from 24 h-BPM: estimated pulse wave velocity (ePWV), early vascular aging ambulatory score (EVAAs), and 24-hour pulse pressure (24 h-PP) were evaluated. Primary outcome was the modified Rankin Scale (mRS) score > 2 at 3 months post-stroke.

resultePWV showed superior predictive value for poor functional outcome (AUC: 0.77, 95% CI: 0.74-0.79) at 3 months post-stroke. Optimal cutoff points for predicting poor functional outcome at 3 months were 12.2 m/s for ePWV (sensitivity: 79.4%, specificity: 61.7%), 65% for EVAAs (sensitivity: 66.4%, specificity: 51.5%), and 51.1mmHg for 24 h-PP (sensitivity: 66.7%, specificity: 46.6%). A new "Severity and Arterial Stiffness" (SASt) score was formulated: SASt = NIHSS + 2*ePWV, which demonstrated excellent discriminatory power for predicting poor functional outcome (AUC: 0.87, 95% CI: 0.85-0.88) at 3 months post-stroke.

conclusionsThe ePWV and the new SASt score show promising potential as tools for identifying patients at higher risk for poor outcomes at 3 months post-stroke. While these findings are encouraging, further prospective studies are needed to validate their utility before they can be adopted in clinical practice.

Indexed as

AgingIschemic StrokeSeverity of Illness IndexStrokeVascular StiffnessAgedAged, 80 and overBlood PressureBlood Pressure Monitoring, AmbulatoryFemaleHumansMaleMiddle AgedPrognosisPulse Wave AnalysisAcute ischemic strokeEstimated arterial stiffnessOutcomePredictionVascular aging

Identifiers

PMID41053532

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.