Evidence map›Paper›PMID 41053531›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Thrombectomy-capable vs. comprehensive stroke centers: impact on endovascular therapy outcomes in acute large vessel occlusion.

Shujuan Gan, Tingyu Yi, Jintao Chen, Wenli Zhang, Yanmin Wu, Meihua Wu, Weifeng Huang, Ya Shao, Lihua Xu, Dongsheng Ju and 2 more

Abstract readMulticenter StudyComparative Study
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

12 authors.

Shujuan GanDepartment of Cerebrovascular Disease, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.ORCID http://orcid.org/0009-0003-4149-1635
Tingyu YiCerebrovascular and Neuro-Intervention Department, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China.
Jintao ChenDepartment of Cerebrovascular Disease, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Wenli ZhangDepartment of Neurology, The Second Hospital of Zhangzhou, Zhangzhou, Fujian, China.
Yanmin WuCerebrovascular and Neuro-Intervention Department, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China.
Meihua WuCerebrovascular and Neuro-Intervention Department, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China.
Weifeng HuangDepartment of Cerebrovascular Disease, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Ya ShaoDepartment of Cerebrovascular Disease, Gansu Provincial Hospital of TCM, Lanzhou, Gansu, China.
Lihua XuDepartment of Neurology, Jiamusi Central Hospital, Jiamusi, Heilongjiang, China.
Dongsheng JuDepartment of Neurology, Songyuan Jilin Oilfield Hospital, Jilin, China.
Liqun Jiao *Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China. liqunjiao@sina.cn.ORCID http://orcid.org/0000-0003-4982-6295
Wenhuo Chen *Department of Cerebrovascular Disease, Fujian Medical University Union Hospital, Fuzhou, Fujian, China. doctorwwenhuo@126.com.ORCID http://orcid.org/0000-0002-7031-8917

Funding

National Health Commission Capacity Building and Continuing Education Center GWJJ2021100203
6 · The paper itself

Abstract

backgroundAlthough data on the outcomes of endovascular therapy (EVT) for acute ischemic stroke in different stroke centers are limited, this study aimed to evaluate EVT quality and outcomes in thrombectomy-capable stroke centers (TSCs) versus comprehensive stroke centers (CSCs) for ischemic stroke patients with large vessel occlusion. MATERIALS AND

methodsThis study included 37 stroke centers (11 CSCs, 26 TSCs) dispersed across 20 provinces. Patients with acute anterior circulation large vessel occlusion within 24 hours of symptom onset were enrolled. Regression models were used to control for baseline characteristics and time metrics to assess outcomes by center type.

resultsA total of 947 patients (423 from TSCs, 524 from CSCs; median age: 69 years; 585 [61.8%] men) who underwent EVT were analyzed. Functional independence (modified Rankin Scale score [mRS] 0-2 at 90 days) was 43.5% in TSCs and 49% in CSCs (adjusted odds ratio [aOR], 1.02; 95% CI, 0.693-1.5). Compared to TSCs, CSCs exhibited lower mortality (aOR, 0.466; 95% CI, 0.284-0.767) and higher rates of successful reperfusion (aOR, 3.29; 95% CI, 1.76-6.15). No significant differences were found in terms of symptomatic intracranial hemorrhage or procedural complications. Sensitivity and subgroup analyses supported these findings.

conclusionsIn patients with anterior circulation large vessel occlusion undergoing EVT, CSCs had similar functional independence rates to TSCs but lower mortality and better reperfusion without higher hemorrhage risk.

Indexed as

Endovascular ProceduresIschemic StrokeThrombectomyAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeAcute ischemic strokeEndovascular therapyLarge vessel occlusionsStroke center accreditation

Identifiers

PMID41053531

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.