Evidence map›Paper›PMID 41053510›Full record

Trial reportBone marrow transplantation2026

Upfront memory T cell add-back with haploidentical TCRαβ-depleted graft in adults with haematological malignancies: a nationwide, multicentre, single-arm, prospective study.

Liang-Piu Koh, Yeh Ching Linn, Yang Liang Boo, Victor Ling, Zi Yi Lim, Michelle Poon, Jeffrey Quek, Hein Than, Colin Phipps Diong, Balamurugan Vellayappan and 18 more

Abstract readMulticenter StudyClinical Trial
PubMed Publisher
In one paragraph

Trial report in Bone marrow transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Liang-Piu KohDepartment of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore. mdcklp@nus.edu.sg.ORCID 0000-0002-8298-647X
Yeh Ching LinnDepartment of Haematology, Singapore General Hospital and National Cancer Center, Singapore, Singapore.ORCID 0000-0001-8098-2590
Yang Liang BooDepartment of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
Victor LingDepartment of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
Zi Yi LimCenter for Clinical Hematology, Mount Elizabeth Novena Medical Center, Singapore, Singapore.
Michelle PoonDepartment of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
Jeffrey QuekDepartment of Haematology, Singapore General Hospital and National Cancer Center, Singapore, Singapore.
Hein ThanDepartment of Haematology, Singapore General Hospital and National Cancer Center, Singapore, Singapore.
Colin Phipps DiongParkway Cancer Center, Mount Elizabeth Hospital, Singapore, Singapore.
Balamurugan VellayappanDepartment of Radiation Oncology, National University Cancer Institute, Singapore, Singapore.
Aloysius HoDepartment of Haematology, Singapore General Hospital and National Cancer Center, Singapore, Singapore.ORCID 0000-0003-1299-8560
Francesca LimDepartment of Haematology, Singapore General Hospital and National Cancer Center, Singapore, Singapore.
William HwangDepartment of Haematology, Singapore General Hospital and National Cancer Center, Singapore, Singapore.ORCID 0000-0003-0143-6263
Lip Kun TanDepartment of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
Jean Rachel M CatapiaDepartment of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
Joanne LeeDepartment of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
Ian WuDepartment of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
Kheng Wei YeohDivision of Radiation Oncology, National Cancer Center Singapore, Singapore, Singapore.
Bryan HoDivision of Radiation Oncology, National Cancer Center Singapore, Singapore, Singapore.
Wen Shen LooiDivision of Radiation Oncology, National Cancer Center Singapore, Singapore, Singapore.
Lawrence NgDepartment of Haematology, Singapore General Hospital and National Cancer Center, Singapore, Singapore.
Tertius Tansloan TuyDepartment of Haematology, Singapore General Hospital and National Cancer Center, Singapore, Singapore.
Yvonne LohCurie Oncology, Mount Elizabeth Hospital, Singapore, Singapore.
Teck Guan SohDepartment of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
Gina GanDepartment of Haematology, Singapore General Hospital and National Cancer Center, Singapore, Singapore.
Kee Khiang HengDepartment of Haematology, Singapore General Hospital and National Cancer Center, Singapore, Singapore.
Yin Jie KohDepartment of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
Wing LeungDepartment of Paediatric Haematology, KK Women's and Children's Hospital, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In haploidentical hematopoietic cell transplantation (Haplo-HCT), in vivo or ex vivo T-cell depletion (TCD) can prevent graft-versus-host disease (GVHD) but increase risk of infection and relapse. We hypothesized that TCRαβ-depleted allograft together with upfront infusion with CD45RA-depleted memory T cells (αβTCD + T

Indexed as

Hematologic NeoplasmsHematopoietic Stem Cell TransplantationLymphocyte DepletionMemory T CellsReceptors, Antigen, T-Cell, alpha-betaTransplantation, HaploidenticalAdolescentAdultAgedFemaleGraft vs Host DiseaseHumansMaleMiddle AgedProspective StudiesYoung AdultReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID41053510

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.