ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025
Oncologic parity in T2 laryngeal cancer: transoral laser surgery and open partial laryngectomy.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Impaired vocal cord mobility due to thyroarytenoid muscle involvement predicts poorer prognosis in T2 glottic cancer. Opportunity for refinement of the TNM 8Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026Review
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Abstract
objectiveThe optimal surgical treatment for T2 laryngeal cancer remains controversial, with both open partial laryngectomy (OPL) and transoral laser microsurgery (TLM) being widely used. This study aims to compare the oncological outcomes of OPL and TLM in patients with T2 laryngeal cancer and identify factors influencing prognosis.
methodsData from 216 patients with T2 laryngeal cancer treated between 2012 and 2022 were retrospectively analyzed. Propensity score matching (PSM) was used to balance covariates between groups. Oncological outcomes were evaluated using overall survival (OS), disease-specific survival (DSS), and local recurrence-free survival (LRFS). Univariate and multivariate Cox regression analyses identified independent risk factors.
resultsA total of 168 patients underwent OPL and 48 underwent TLM. After PSM, 53 OPL and 26 TLM patients were matched. Significant differences in smoking history, drinking history, and tumor characteristics were diminished post-PSM. No significant differences in OS, DSS, or LRFS were observed between OPL and TLM, both before and after PSM. Multivariate analysis identified age > 65 years, female gender, impaired vocal cord mobility, and low differentiation as significant predictors of OS. Additionally, age > 65 years was associated with DSS and LRFS. After PSM, age > 65 years and female gender remained significant predictors of OS. Drinking history was associated with DSS, and female gender was associated with LRFS.
conclusionGiven TLM's functional advantages and similar oncological outcomes with OPL, it is recommended as the first-line treatment for T2 glottic and supraglottic carcinoma. LEVEL OF EVIDENCE: 3:
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