ArticleMolecular psychiatry2026
Regulation of stress susceptibility by chromatin-binding protein PHF6 in the pituitary intermediate lobe.
Bing Liu, Jingjie Wang, Xiaohua Wu, Linhua Gan, Jingjing Sun, Guangzhong Wang, Qian Li, Ju Huang
Abstract read
In one paragraphArticle in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Bing Liu *Department of Neurology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Jingjie Wang *Department of Neurology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Xiaohua WuDepartment of Neurology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Linhua GanDepartment of Neurology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Jingjing SunDepartment of Neurology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Guangzhong WangCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.ORCID 0000-0001-6432-8310 Qian LiDepartment of Neurology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.ORCID 0000-0003-1300-3377 Ju HuangDepartment of Neurology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China. juhuang@shsmu.edu.cn.ORCID 0000-0003-4280-0690 Funding
Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021ZD0202800/01National Natural Science Foundation of China (National Science Foundation of China) 32070957,81771215National Natural Science Foundation of China (National Science Foundation of China) 32200820National Natural Science Foundation of China (National Science Foundation of China) 32300838
6 · The paper itselfAbstract
The pituitary intermediate lobe (IL) is a surprisingly understudied pituitary region. Here, we find that chromatin-binding protein PHF6 is enriched in the pituitary IL and plays a crucial role in regulating stress susceptibility in mice. Conditional knockout of Phf6 in PHF6-positive IL cells (
Indexed as
Stress, PsychologicalAnimalsAnxietyChromatinCorticotropin-Releasing HormoneDepressionMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsParaventricular Hypothalamic NucleusPituitary GlandChromatinCorticotropin-Releasing Hormone
Identifiers
PMID41053436
PMCPMC12916324
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