Evidence map›Paper›PMID 41053435›Full record

SynthesisMolecular psychiatry2025

Cortical 5-HT

George E Chapman, George Turner, Alexander P Noar, Tommaso Barba, Rayyan Zafar, Robert A McCutcheon, David Erritzoe

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

George E ChapmanDivision of Psychiatry, Faculty of Brain Sciences, University College London, London, UK. george.chapman@ucl.ac.uk.ORCID http://orcid.org/0000-0001-7874-0314
George TurnerDivision of Psychiatry, Faculty of Brain Sciences, University College London, London, UK.ORCID http://orcid.org/0000-0001-5711-762X
Alexander P NoarDivision of Psychiatry, Faculty of Brain Sciences, University College London, London, UK.ORCID http://orcid.org/0000-0003-2180-9792
Tommaso BarbaCentre for Psychedelic Research, Imperial College London, London, UK.
Rayyan ZafarCentre for Psychedelic Research, Imperial College London, London, UK.
Robert A McCutcheonDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1102-2566
David ErritzoeCentre for Psychedelic Research, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-7022-6211

Funding

Wellcome TrustWellcome Trust (Wellcome) 224625/Z/21/Z
6 · The paper itself

Abstract

introductionMajor depressive disorder (MDD) is a leading cause of suicide and disability. Better understanding changes to serotonin

methodsDatabases were searched from inception to August/September 2024. Binding data were extracted and pooled before random-effects meta-analyses of mean difference (Hedges' g) and variance were undertaken. Simple linear regression was performed to investigate the relationship between receptor binding and depression severity at baseline in PET and SPECT studies. We also assessed study quality and tested for evidence of publication bias.

resultsData on 556 MDD patients or suicide victims and 526 controls from 31 studies were included. Cortical 5-HT

conclusionIn vivo 5-HT

Indexed as

Cerebral CortexDepressionMajor Depressive DisorderReceptor, Serotonin, 5-HT2ASuicideHumansMalePositron-Emission TomographyPostmortem ImagingTomography, Emission-Computed, Single-PhotonReceptor, Serotonin, 5-HT2A

Identifiers

PMID41053435
PMCPMC12602341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.