ArticlePediatric research2026
White matter microstructure and gray matter density in 12-year-old preterm born children.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate white matter microstructure and gray matter densities in 12-year-old children born very preterm and evaluate potential effects of antenatal steroids and intraventricular hemorrhage (IVH).
methodsBrain MRI (3Tesla) was performed in 57 children born very preterm, 16 with IVH and 41 treated with antenatal corticosteroids, and in 22 full-term controls. White matter microstructure and gray matter density were compared between groups using tract-based spatial statistics (TBSS) and voxel-based morphometry (VBM).
resultsPreterm-born children showed no differences in white matter fractional anisotropy (FA) compared to controls, but showed increased or decreased gray matter density in several regions. In the preterm group, lower gestational age was associated with reduced FA in the anterior commissure and the anterior parts of the inferior fronto-occipital fasciculus. Antenatal steroid exposure did not affect FA or gray matter density. IVH was associated with decreased gray matter density in the temporo-occipital cortex.
conclusionVery premature birth is associated with alterations in gray matter density, and there is a correlation between gestational age and white matter integrity. Antenatal steroid exposure does not affect white matter integrity or gray matter density, but IVH exposure is associated with locally decreased gray matter density. IMPACT: Prematurely born adolescents show differences in gray matter density in several regions compared to controls, with both increased and decreased values observed. In prematurely born adolescents, there is a correlation between lower gestational age and reduced white matter integrity. Assessment of white matter microstructure using tract-based spatial statistics (TBSS) and gray matter volumes using voxel-based morphometry (VBM) in the same cohort of subjects shows alterations in regions involving the same neural circuit.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.