SynthesisEye (London, England)2025
Significance of serum biomarkers in preterm infants screened for retinopathy of prematurity: a systematic review and meta-analysis.
Synthesis in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The predictive role of early and late-stage inflammatory markers in the development of retinopathy of prematurity in discordant twins.Eye (London, England) · 2026Article
- Construction of a prediction model for retinopathy of prematurity based on placenta-derived genes and clinical variables.Translational pediatrics · 2026Article
- Supplementation with long-chain polyunsaturated fatty acids to extremely preterm infants associates with development of the intestinal microbiota.Pediatric research · 2026Article
- Comment on: Significance of serum biomarkers in preterm infants screened for retinopathy of prematurity: a systematic review and meta-analysis.Eye (London, England) · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesRetinopathy of prematurity (ROP) is a leading cause of childhood blindness. This systematic review and meta-analysis assess the association between eight serum biomarkers and the presence of ROP in premature neonates. These biomarkers are neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), red cell distribution width (RDW), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), platelet mass index (PMI), systemic immune-inflammation index (SII), and vitamin D. SUBJECTS/
methodsA comprehensive literature search was conducted across PubMed, Embase, Scopus, and Cochrane Library for studies published up to February 2025. Eligible studies included quantitative data on serum biomarker levels in premature neonates with and without ROP. A random-effects meta-analysis estimated standardised mean differences (SMDs) and 95% confidence intervals (CIs). Risk of bias was assessed using the Newcastle-Ottawa Scale.
resultsTwenty-one studies comprising 3965 participants were included. Significant associations were found for NLR (SMD = 0.43, 95% CI: 0.16-0.71, P = 0.002), RDW (SMD = 0.41, 95% CI: 0.15-0.67, P = 0.002), and vitamin D (SMD = -1.18, 95% CI: -1.47--0.90, P < 0.00001). CRP, LMR, PLR, PMI, and SII did not show significant associations with ROP presence.
conclusionsNLR, RDW, and vitamin D levels are potential biomarkers associated with ROP presence in premature neonates, likely reflecting systemic inflammation and vascular pathology. Further large-scale prospective studies are warranted to establish standardised cutoff values for clinical implementation.
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