ArticleScientific reports2025
Probiotics as a therapeutic approach to alleviate reproductive harm from polystyrene microplastics in male rats.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Prenatal road traffic noise impairs early testicular development in Sprague-Dawley offspring: pharmacological rescue by melatonin and edaravone; developmental preservation by environmental enrichment.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- 4-Phenylbutyric acid attenuates endoplasmic reticulum stress-mediated polystyrene microplastic-induced nephrotoxicity in Wistar rats.Molecular biology reports · 2026Article
- Effects of Microplastics on the Central Reproductive Neuroendocrine System in a Sheep Model.International journal of molecular sciences · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microplastics (MP) are considered as a new persistent environmental pollutant. The study investigated the impact of probiotics on reproductive toxicity induced by polystyrene microplastics (PS-MP). It was observed that PS-MP administration caused dose-dependent testicular damage and negatively regulated the expression of kisspeptin and its receptors in the hypothalamus. However, supplementation of probiotics significantly mitigated oxidative stress and inflammation in cell experiments. In animal experiments, probiotics were found to improve testicular damage, decrease sperm nitric oxide, and increase blood levels of sex hormones in a dose-dependent manner. These findings suggest that probiotics may play a role in reducing testicular damage caused by PS-MP through their anti-inflammatory and antioxidant properties. This study provides valuable insights into mitigating the reproductive damage associated with microplastic exposure and offers a new approach to addressing microplastic toxicology for reproductive health.
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