Evidence map›Paper›PMID 41053334›Full record

ArticleScientific reports2025

The role of vitamin C in melanoma cell death via activation of cytochrome C and TNF-α protein expression.

Eva Krishna Sutedja, Tiara Rachmaputeri Arianto, Ghabrina Saraswati Elgianda, Endang Sutedja, Ronny Lesmana, Oki Suwarsa, Reti Hindritiani, Pati Aji Achdiat, Hendra Gunawan, Budi Setiabudiawan

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eva Krishna SutedjaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjajaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia. eva.krishna@unpad.ac.id.
Tiara Rachmaputeri AriantoDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjajaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
Ghabrina Saraswati ElgiandaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjajaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
Endang SutedjaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjajaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
Ronny LesmanaDepartment of Physiology, Faculty of Medicine, Universitas Padjajaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
Oki SuwarsaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjajaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
Reti HindritianiDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjajaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
Pati Aji AchdiatDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjajaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
Hendra GunawanDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjajaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
Budi SetiabudiawanDepartment of Child Health, Faculty of Medicine, Universitas Padjajaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the effect of vitamin C on cytochrome c and TNF-α expression, representing intrinsic and extrinsic apoptotic pathways in B16-F10 melanoma cells. B16-F10 melanoma cells (ATCC

Indexed as

Ascorbic AcidCytochromes cMelanomaMelanoma, ExperimentalTumor Necrosis Factor-alphaAnimalsApoptosisCaspase 3Caspase 9Cell Line, TumorGene Expression Regulation, NeoplasticInterleukin-6MiceAscorbic AcidCaspase 3Caspase 9Cytochromes cInterleukin-6Tumor Necrosis Factor-alphaApoptosisCytochrome cExtrinsic pathwayIntrinsic pathwayTNF-αVitamin c

Identifiers

PMID41053334
PMCPMC12500876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.