Evidence map›Paper›PMID 41053315›Full record

ArticleEMBO reports2025

Arginine methylation-dependent METTL14-SMN interaction regulates RNA m

Yi Zhang, Lei Shen, Lili Ren, Jiangbo Wei, Hoang Quoc Hai Pham, Xiaoqun Tao, Jiamin Guo, Zhihao Wang, Binghui Shen, Rui Su and 2 more

Abstract read
In one paragraph

Article in EMBO reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yi ZhangDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID 0000-0003-3419-2461
Lei ShenDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Lili RenDepartment of System Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID 0009-0002-3588-7214
Jiangbo WeiDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and the Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, 60637, USA.
Hoang Quoc Hai PhamDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID 0000-0002-9044-5008
Xiaoqun TaoDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Jiamin GuoIrell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID 0000-0002-8441-1266
Zhihao WangDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Binghui ShenDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID 0000-0002-4408-407X
Rui SuDepartment of System Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Chuan HeDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and the Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0003-4319-7424
Yanzhong YangDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA, USA. yyang@coh.org.ORCID 0000-0002-1937-4526

Funding

Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4M
Regulation of N6-methyladenosine (m6A) deposition by arginine methylationR01GM133850 · NIGMS · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI YANG, YANZHONG · 2019 to 2023
$2.1M
Biological function and regulation of PRMT9 in synapse developmentR01NS132083 · NINDS · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Yanzhong Yang · 2024 to 2026
$1.8M
Protein arginine methylation in transcription and RNA metabolismR35GM156316 · NIGMS · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Yanzhong Yang · 2025 to 2026
$890k
HHS | NIH | National Human Genome Research Institute (NHGRI) RM1HG008935HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM133850HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM156316HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS132083NHGRI NIH HHS RM1 HG008935NIGMS NIH HHS R01 GM133850NIGMS NIH HHS R35 GM156316NINDS NIH HHS R01 NS132083
6 · The paper itself

Abstract

N6-methyladenosine (m

Indexed as

AdenosineArginineHomeostasisMethyltransferasesSurvival of Motor Neuron 1 ProteinAnimalsDisease Models, AnimalDNA RepairFibroblastsHumansMethylationMiceMuscular Atrophy, SpinalMutationProtein BindingAdenosineArginineMethyltransferasesMETTL14 protein, humanMettl14 protein, mouseN-methyladenosineSurvival of Motor Neuron 1 ProteinArginine MethylationGenome StabilityHematopoiesisMETTL14SMN

Identifiers

PMID41053315
PMCPMC12635257

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.