Evidence map›Paper›PMID 41053185›Full record

ArticleNature communications2025

Cells adapt to extracellular acidic pH through TM9SF3-mediated PI(4,5)P

Keisuke Sako, Yusuke V Morimoto, Shin Morioka, Junya Hasegawa, Hiroyuki Nakajima, Moe Fukumoto, Yuya Nishida, Yasunori Shintani, Junko Sasaki, Takehiko Sasaki and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Keisuke SakoDepartment of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan. sako@keio.jp.ORCID http://orcid.org/0000-0002-6453-8075
Yusuke V MorimotoDepartment of Physics and Information Technology, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka, Fukuoka, Japan.ORCID http://orcid.org/0000-0003-1573-8967
Shin MoriokaDepartments of Lipid Biology, Biochemical Pathophysiology, and Cellular and Molecular Medicine, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.
Junya HasegawaDepartments of Lipid Biology, Biochemical Pathophysiology, and Cellular and Molecular Medicine, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0003-1216-7468
Hiroyuki NakajimaDepartment of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.ORCID http://orcid.org/0000-0003-4139-2779
Moe FukumotoDepartment of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
Yuya NishidaDepartment of Molecular Pharmacology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.ORCID http://orcid.org/0000-0002-1994-0807
Yasunori ShintaniDepartment of Molecular Pharmacology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.ORCID http://orcid.org/0000-0001-9579-0727
Junko SasakiDepartments of Lipid Biology, Biochemical Pathophysiology, and Cellular and Molecular Medicine, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.
Takehiko SasakiDepartments of Lipid Biology, Biochemical Pathophysiology, and Cellular and Molecular Medicine, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.
Kazu KikuchiDepartment of Cardiac Regeneration Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.ORCID http://orcid.org/0000-0002-4681-4275
Naoki MochizukiDepartment of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan. mochizuki@ncvc.go.jp.ORCID http://orcid.org/0000-0002-3938-9602

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 19H01022MEXT | Japan Society for the Promotion of Science (JSPS) 24K09294, 21K05983MEXT | JST | Center of Innovation Program (COI) JPMJPF2018, JPMJMS2024-3MEXT | JST | Precursory Research for Embryonic Science and Technology (PRESTO) JPMJPR204B
6 · The paper itself

Abstract

The plasma membrane (PM), a physical barrier separating cells from their environment, responds to fluctuating extracellular environment through receptor-mediated signaling. While these pathways have been extensively studied, the role of PM lipids remains poorly understood. Here, we show that phosphatidylinositol 4,5-bisphosphate (PIP

Indexed as

Membrane ProteinsPhosphatidylinositol 4,5-DiphosphateZebrafish ProteinsAnimalsCell MembraneCell MovementCytoskeletonExtracellular FluidGastrulationHydrogen-Ion ConcentrationMesodermSignal TransductionZebrafishMembrane ProteinsPhosphatidylinositol 4,5-DiphosphateZebrafish Proteins

Identifiers

PMID41053185
PMCPMC12500971

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.