Evidence map›Paper›PMID 41053135›Full record

ArticleNPJ vaccines2025

Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination.

Ruth A Purcell, Marios Koutsakos, Lukasz Kedzierski, Lilith F Allen, Oscar H Lloyd Williams, Jo-Wai Douglas Wang, George Cavic, Adam K Wheatley, Wen Shi Lee, Bruce D Wines and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Ruth A PurcellDepartment of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia. purcellr@student.unimelb.edu.au.
Marios KoutsakosDepartment of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Lukasz KedzierskiDepartment of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Lilith F AllenDepartment of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Oscar H Lloyd WilliamsDepartment of Infectious Diseases, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Jo-Wai Douglas WangDepartment of Medical Oncology, The Canberra Hospital, Canberra, ACT, Australia.
George CavicResearch School of Biology, Australian National University, Canberra, ACT, Australia.
Adam K WheatleyDepartment of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Wen Shi LeeDepartment of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Bruce D WinesImmune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.
P Mark HogarthImmune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.
Emily M ErikssonInfection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Ivo MuellerInfection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Katherine A BondDepartment of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Deborah A WilliamsonDepartment of Infectious Diseases, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Janine M TrevillyanDepartment of Infectious Diseases, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Jason A TrubianoCentre for Antibiotic Allergy and Research, Austin Health, Heidelberg, VIC, Australia.
Thi H O NguyenDepartment of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Pradhipa RamanathanDepartment of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Stephen J RogersonDepartment of Infectious Diseases, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Kelly B ArnoldDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Kanta SubbaraoDepartment of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Adrian LeeSydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Amanda L HudsonBill Walsh Translational Cancer Research Laboratory, Kolling Institute, Royal North Shore Hospital, Northern Sydney Local Health District, St. Leonards, NSW, Australia.
Alexander YuileSydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Helen R WheelerSydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Stephen J KentDepartment of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Kevin John SelvaDepartment of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Siddhartha MahantyDepartment of Infectious Diseases, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Katherine KedzierskaDepartment of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Aude M FahrerResearch School of Biology, Australian National University, Canberra, ACT, Australia.
Yada KanjanapanDepartment of Medical Oncology, The Canberra Hospital, Canberra, ACT, Australia.
Amy W ChungDepartment of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia. awchung@unimelb.edu.au.

Funding

Centers of Excellence for Influenza Research and Response (CEIRR) #HHSN272201400005CMedical Research Future Fund MRFF #2016062National Health and Medical Research Council Ideas grant #2029642National Health and Medical Research Council Investigator grantNational Health and Medical Research Council Investigator grant #2008092National Health and Medical Research Council L1 Investigator grant #1173871NIH HHS HHSN272201400005CWHO Unity funds 2020/1085469-0
6 · The paper itself

Abstract

Solid tumor malignancy (STM) patients experience increased risk of breakthrough SARS-CoV-2 infection owing to reduced COVID-19 vaccine immunogenicity. However, the underlying immunological causes of impaired neutralization remain poorly characterized. Furthermore, non-neutralizing antibody functions can contribute to reduced disease severity but remain understudied within high-risk populations. We dissected polyfunctional antibody responses in STM patients and age-matched controls who received adenoviral vector- or mRNA-based COVID-19 vaccine regimens. Elevated inflammatory biomarkers, including agalactosylated IgG, interleukin (IL)-6, IL-18, and an expanded population of CD11c

Identifiers

PMID41053135
PMCPMC12501030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.