Evidence map›Paper›PMID 41053123›Full record

ArticleScientific reports2025

A monoclonal antibody selectively recognizing PfEMP1 proteins associated with cerebral malaria.

Nanna Dalgaard, Rebecca W Olsen, Yvonne Adams, Blanca L Mendez, Jonas J Rudbaek, Sofie Amalie G Bisholm, Azizath Mousiliou, Melanie R Walker, Lars Hviid, Rachida Tahar and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nanna DalgaardCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Rebecca W OlsenCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Yvonne AdamsCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Blanca L MendezBiophysics Platform, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jonas J RudbaekCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sofie Amalie G BisholmCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Azizath MousiliouUniversité de Paris Cité, MERIT, IRD, Paris, 75006, France.
Melanie R WalkerCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lars HviidCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Rachida TaharUniversité de Paris Cité, MERIT, IRD, Paris, 75006, France.
Nicaise T NdamUniversité de Paris Cité, MERIT, IRD, Paris, 75006, France.
Lea BarfodCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. lbarfod@sund.ku.dk.
Anja R JensenCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Funding

Lundbeck Foundation R313-2019-322Novo Nordisk Fonden NNF170C0026778
6 · The paper itself

Abstract

The frequently fatal outcome of cerebral malaria has been linked to the adhesion and accumulation in the cerebral microvasculature of infected erythrocytes (IEs), which express a particular type of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). This type, found in the A and B/A subsets of PfEMP1, contains a particular structural motif (DBLβ

Indexed as

Antibodies, MonoclonalMalaria, CerebralPlasmodium falciparumProtozoan ProteinsAnimalsEpitopesErythrocytesHumansIntercellular Adhesion Molecule-1MiceProtein BindingAntibodies, MonoclonalEpitopeserythrocyte membrane protein 1, Plasmodium falciparumIntercellular Adhesion Molecule-1Protozoan Proteins

Identifiers

PMID41053123
PMCPMC12501059

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.