Evidence map›Paper›PMID 41053093›Full record

ArticleCell death & disease2025

Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions.

Juliette Tokgozoglu, Valeria Pistorio, Mirko Minini, Pierre-Antoine Soret, Virginie Steunou, Jean-Louis Delaunay, Julien Castel, Serge Luquet, Ivan Nemazanyy, Carine Beaupère and 12 more

Abstract read
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Juliette Tokgozoglu *Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.
Valeria Pistorio *Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.ORCID http://orcid.org/0000-0001-7624-9660
Mirko MininiSorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.ORCID http://orcid.org/0000-0001-9780-4643
Pierre-Antoine SoretSorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.
Virginie SteunouSorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.
Jean-Louis DelaunaySorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.
Julien CastelUniversité Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, F-75013, France.
Serge LuquetUniversité Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, F-75013, France.
Ivan NemazanyyParis Cité Université, INSERM, Structure Fédérative de Recherche Necker, Platform for Metabolic Analyses, F-75015, Paris, France.ORCID http://orcid.org/0000-0001-8080-839X
Carine BeaupèreSorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.
Laetitia DinardSorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.
Tatiana LedentSorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.
Aurore L'honoréSorbonne Université, INSERM, Institut de Biologie Paris Seine, IBPS, F-75005, Paris, France.
Sara LemoinneSorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.
Chantal HoussetSorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.
Philippe LesnikFoundation for Innovation in Cardiometabolism And Nutrition, IHU-ICAN, F-75013, Paris, France.ORCID http://orcid.org/0000-0002-6909-7715
Vlad RatziuFoundation for Innovation in Cardiometabolism And Nutrition, IHU-ICAN, F-75013, Paris, France.
Bruno FèveSorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.
Tounsia Aït-SlimaneSorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.
Axelle CadoretSorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.
Nicolas ChignardSorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.ORCID http://orcid.org/0000-0002-2680-1864
Jérémie GautheronSorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France. jeremie.gautheron@inserm.fr.ORCID http://orcid.org/0000-0002-7727-9893

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-21-CE17-0002Agence Nationale de la Recherche (French National Research Agency) ANR-24-CE52-5278Société Francophone du Diabète (SFD) C24/0316Société Francophone du Diabète (SFD) R19114DD
6 · The paper itself

Abstract

Obesity is a global epidemic characterized by chronic low-grade inflammation and metabolic dysfunction, with adipose tissue playing a pivotal role in these processes. The mixed lineage kinase domain-like pseudokinase (MLKL) is a critical mediator of necroptosis but also exhibits noncanonical roles in metabolic regulation. This study aimed to investigate the adipocyte-specific functions of MLKL in obesity. Using adipocyte-specific Mlkl knockout (Mlkl

Indexed as

AdipocytesMitochondriaObesityProtein KinasesAdipose Tissue, WhiteAnimalsDiet, High-FatEnergy MetabolismInsulin ResistanceLipid MetabolismMaleMiceMice, Inbred C57BLMice, KnockoutMLKL protein, mouseProtein Kinases

Identifiers

PMID41053093
PMCPMC12501060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.