Evidence map›Paper›PMID 41053026›Full record

ArticleTranslational psychiatry2025

Antimicrobial treatment ameliorates delirium-like phenotypes in a murine model of urinary tract infection.

Kevin D Winzey, Landon Scott, Debbie Moreira, Timothy S Islam, Catherine Bresee, Jean Phillipe Vit, Warren G Tourtellotte, Konrad H Schlick, Fayyaz S Sutterwala, S Ananth Karumanchi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kevin D Winzey *Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0003-4555-1471
Landon Scott *Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0001-2407-0279
Debbie MoreiraDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Timothy S IslamDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0008-7903-9448
Catherine BreseeBiostatistics Shared Resources, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jean Phillipe VitDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Warren G TourtellotteDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Konrad H SchlickDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Fayyaz S SutterwalaDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
S Ananth KarumanchiDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Shouri LahiriDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. shouri.lahiri@csmc.edu.ORCID http://orcid.org/0000-0002-5469-6467

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Practice guidelines recommend withholding antimicrobial therapy (ABX) in delirious patients with suspected urinary tract infection (UTI) who do not endorse classic genitourinary symptoms, citing both a lack of a causal relationship between bacteriuria and delirium and benefit from ABX. In this study, we tested the hypothesis that UTI induces delirium-like phenotypes that are mitigated by ABX. Escherichia coli (CFT073) UTI was induced in female C57BL/6 J mice aged 4-5 months. Mice were randomized to receive one dose of ceftriaxone 600 mg/kg (n = 23) or saline (n = 21) one day after induction of UTI. Delirium-like behaviors were assessed using Open Field, Elevated Plus Maze, and Y-maze, while neurostructural changes were evaluated using neuronal cleaved caspase-3 (CC3) and interleukin-6 (IL-6) via immunohistochemistry. Plasma IL-6 was quantified using ELISA. Compared to vehicle-treated mice, ABX mice with UTI demonstrated: 1) decreased time in the periphery of the Open Field maze (p = 0.017), 2) decreased time in the closed arms of the Elevated Plus Maze (p = 0.013), and 3) increased spontaneous alternations in Y-maze (p = 0.015). These behavioral changes were accompanied by significantly lower frontal/hippocampal CC3 (p = 0.0038, p = 0.0003, respectively) and IL-6 (p = 0.015) levels in ABX- compared to vehicle-treated UTI mice. ABX significantly lowered plasma IL-6 compared to vehicle-treated UTI mice (p < 0.01). This study suggests a causal relationship between UTI and functional/neurostructural delirium-like phenotypes that are attenuated with ABX. These findings provide strong rationale for a randomized clinical trial to evaluate the role of ABX in patients with delirium as the isolated presumed sign of UTI.

Indexed as

Anti-Bacterial AgentsBehavior, AnimalCeftriaxoneDeliriumEscherichia coli InfectionsUrinary Tract InfectionsAnimalsCaspase 3Disease Models, AnimalFemaleInterleukin-6MiceMice, Inbred C57BLPhenotypeAnti-Bacterial AgentsCaspase 3CeftriaxoneInterleukin-6

Identifiers

PMID41053026
PMCPMC12501002

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.