Evidence map›Paper›PMID 41052996›Full record

ArticleTranslational psychiatry2025

The antioxidant N-acetylcysteine prevents cortical neuropathological phenotypes caused by adolescent Δ-9-tetrahydrocannabinol exposure in male rats.

Hanna J Szkudlarek, Rajkamalpreet Singh Mann, Krystyna Wieczerzak, Mohammed Halit Sarikahya, Taygun C Uzuneser, Marta De Felice, Mar Rodríguez-Ruiz, Juan Pablo Galindo, Mathusha Pusparajah, Shawn N Whitehead and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hanna J SzkudlarekAddiction Research Group, University of Western Ontario, London, ON, Canada.
Rajkamalpreet Singh Mann *Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada.
Krystyna Wieczerzak *Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada.
Mohammed Halit SarikahyaAddiction Research Group, University of Western Ontario, London, ON, Canada.ORCID http://orcid.org/0000-0002-5511-2638
Taygun C UzuneserAddiction Research Group, University of Western Ontario, London, ON, Canada.
Marta De FeliceAddiction Research Group, University of Western Ontario, London, ON, Canada.
Mar Rodríguez-RuizAddiction Research Group, University of Western Ontario, London, ON, Canada.ORCID http://orcid.org/0000-0002-1583-5997
Juan Pablo GalindoDepartment of Chemistry, University of Western Ontario, London, ON, Canada.
Mathusha PusparajahDepartment of Chemistry, University of Western Ontario, London, ON, Canada.
Shawn N WhiteheadDepartment of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada.
Walter J RushlowAddiction Research Group, University of Western Ontario, London, ON, Canada.
Daniel B HardyDepartment of Physiology and Pharmacology; Schulich School of Medicine & Dentistry; University of Western Ontario, London, ON, Canada.ORCID http://orcid.org/0000-0001-5445-273X
Susanne SchmidDepartment of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada.ORCID http://orcid.org/0000-0001-5366-8061
Ken K-C YeungDepartment of Chemistry, University of Western Ontario, London, ON, Canada.ORCID http://orcid.org/0000-0001-6933-2941
Steven R LavioletteAddiction Research Group, University of Western Ontario, London, ON, Canada. steven.laviolette@schulich.uwo.ca.

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) MOP-123378
6 · The paper itself

Abstract

Clinical and pre-clinical evidence demonstrates that adolescent Δ-9-tetrahydrocannabinol (THC) exposure, the primary psychoactive component of cannabis, increases the risk of developing neuropsychiatric symptoms in later life. The medial prefrontal cortex (mPFC) serves as a pathophysiological nexus point underlying many cannabis-related pathophysiological outcomes. Nevertheless, the molecular mechanisms underlying these risk factors are poorly understood. THC increases oxidative stress, which is a well-established causal factor for increased neuropsychiatric risk, including schizophrenia. N-acetylcysteine (NAC) is an antioxidant glutathione precursor that normalizes glutamate and GABA activity in neuropathological states. We examined if NAC may prevent the pathophysiological impacts of THC using a rodent model of adolescent brain development and chronic THC exposure. We report that NAC treatment prevents cognitive, synaptic, neuronal and neurochemical deficits induced by adolescent THC. These findings highlight the critical role of THC-induced oxidative stress as a contributing factor to cannabinoid-mediated neuropsychiatric risk and identifies a novel antioxidant treatment candidate for the prevention and/or reversal of these pathophysiological outcomes.

Indexed as

AcetylcysteineAntioxidantsDronabinolOxidative StressPrefrontal CortexAnimalsDisease Models, AnimalMalePhenotypeRatsRats, Sprague-DawleyAcetylcysteineAntioxidantsDronabinol

Identifiers

PMID41052996
PMCPMC12501310

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.