ArticleTranslational psychiatry2025
Prefrontal cortical NR2B-containing NMDA receptors are essential for spatial working memory performance.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- The Kynurenine Pathway: Unraveling Its Role in Neurological Disorders via Mammalian Cellular Models.International journal of molecular sciences · 2026Review
- Dynamical mechanisms for coordinating long-term working memory based on the precision of spike-timing in cortical neurons.Biological cybernetics · 2026Review
- Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
NR2A and NR2B are the major GluR2 subunits of N-methyl-D-aspartate (NMDA) receptor. NR2B-containing NMDA receptor was found to be exclusively expressed in post-synapses in layer III pyramidal cells of the prefrontal cortex (PFC). Many studies have suggested the importance of PFC NR2B-containing NMDA receptor for working memory, especially for the persistent delay cell firing. However, direct evidence for the necessity of PFC NR2B-containing NMDA receptor on working memory is still absent, especially in non-human primates. Here, we directly evaluated the necessity of PFC synaptic NR2B for working memory in both rats and monkeys. We first examined the synaptosome expression ratio of NR2B/2A in the PFC, hippocampus and visual cortex, and confirmed a relatively higher expression ratio of NR2B/2A in the PFC than in the hippocampus and visual cortex in both species. We then investigated the effects of intra-PFC blockade of NR2B on the performance of spatial working memory and pattern discrimination, and found that the spatial working memory, but not pattern discrimination, was robustly impaired in a delay length-dependent way in both species. The present study provided behavioral and neuropharmacological evidence for the critical role of PFC NR2B-containing receptors in working memory performance in non-human primates.
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