Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Translational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI Matthew J Girgenti · 2001 to 2026
$43.7M
Yale-SCORE Resource Support CoreU54AA027989 · NIAAA · YALE UNIVERSITY · PI Ralitza Gueorguieva · 2020 to 2026
$13.0M
Genetic & Social Determinants of Health: Center for Admixture Science and TechnologyRM1HG011558 · NHGRI · YALE UNIVERSITY · PI FRAZER, KELLY A, GYMREK, MELISSA · 2021 to 2025
$11.2M
Radiochemistry CoreP30DA046345 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KRANZLER, HENRY RICHARD, MACH, ROBERT H · 2019 to 2023
$9.4M
Methamphetamine and Other Substance Use Disorder Genetics in ThailandR01DA037974 · NIDA · YALE UNIVERSITY · PI JOEL GELERNTER, Marc N Potenza · 2015 to 2026
$6.7M
Linkage Disequilibrium Studies of Alcohol DependenceR01AA011330 · NIAAA · YALE UNIVERSITY · PI GELERNTER, JOEL · 1997 to 2013
$6.4M
Genetics of Cocaine DependenceR01DA018432 · NIDA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KRANZLER, HENRY RICHARD · 2006 to 2010
$3.5M
Leveraging GWAS Findings to Map Variants and Identify Novel Effector Genes for Alcohol-Related TraitsR01AA030056 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI Struan F A Grant, MATTHEW S KAYSER · 2023 to 2026
$2.5M
Deciphering the single-nucleus genomic regulatory structure of opioid use disorder in the human brainDP1DA058737 · NIDA · YALE UNIVERSITY · PI Janitza Liz Montalvo-Ortiz · 2023 to 2026
$2.0M
Genetics of Alcohol Dependence in African Americans: RecruitmentR01AA026364 · NIAAA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2018 to 2022
$2.0M
Cost and Health Outcomes of Risky Drinking in an HMOR01AA012890 · NIAAA · KAISER FOUNDATION RESEARCH INSTITUTE · PI LYNCH, FRANCES L · 2002 to 2004
$790k
Finding the missing parts of human genetics of substance use disordersR21DA063120 · NIDA · YALE UNIVERSITY · PI ZHOU, HANG · 2025 to 2025
$358k
BLRD VA I01 BX004820BLRD VA I01 BX006482CSRD VA I01 CX001849NHGRI NIH HHS RM1 HG011558NIAAA NIH HHS P50 AA012870NIAAA NIH HHS R01 AA011330NIAAA NIH HHS R01 AA012890NIAAA NIH HHS R01 AA026364NIAAA NIH HHS R01 AA030056NIAAA NIH HHS U54 AA027989NIDA NIH HHS DP1 DA058737NIDA NIH HHS P30 DA046345NIDA NIH HHS R01 DA018432NIDA NIH HHS R01 DA037974NIDA NIH HHS R21 DA063120Office of Research and Development (VHA Office of Research and Development) 1I01CX001849
6 · The paper itself
Abstract
Opioid dependence (OD) is epidemic in the United States and it is associated with a variety of adverse health effects. Its estimated heritability is ~50% in twin studies, and recent genome-wide association studies have identified more than a dozen common risk variants. However, there are no published studies of rare OD risk variants. In this study, we analyzed whole-exome sequencing data from the Yale-Penn cohort, comprising 2100 participants of European ancestry (EUR; 1321 OD cases) and 1790 of African ancestry (AFR; 864 cases). A novel low-frequency variant (rs746301110) in the RUVBL2 gene was identified in EUR (p = 6.59 × 10
Indexed as
Exome SequencingOpioid-Related DisordersAdultATPases Associated with Diverse Cellular ActivitiesBlack PeopleFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedWhiteWhite PeopleATPases Associated with Diverse Cellular Activities
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants. · full record | OpenQuestion