ArticleTranslational psychiatry2025
Psychedelic compounds directly excite 5-HT
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Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- A suite of engineered mice for interrogating psychedelic drug actions.Nature neuroscience · 2026Article
- No evidence for direct physical interaction of 5-HTbioRxiv : the preprint server for biology · 2026Article
- Mechanistic insights toward dissociating therapeutic from psychedelic effects: bridging the gap between psychedelic research and mental health care.Translational psychiatry · 2026Review
- Temporal assessment of behavior in Parkinson's visual hallucinations via a multidimensional analysis strategy.Signal transduction and targeted therapy · 2026Article
- Psychedelic 5-HT2A agonist increases spontaneous and evoked 5-Hz oscillations in visual and retrosplenial cortex.Communications biology · 2026Article
- Circuit-selective pharmacological targeting of prefrontal cortex-projecting locus coeruleus neurons drives antinociception.Cell reports · 2025Article
- The impact of the serotonergic psychedelic DOI on active vision in freely moving mice.bioRxiv : the preprint server for biology · 2025Article
- The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.Neuron · 2025Article
- The Role of Psychedelics in Contemporary Psychological and Interdisciplinary Inquiry.Journal of personalized medicine · 2025Review
- A suite of engineered mice for interrogating psychedelic drug actions.bioRxiv : the preprint server for biology · 2023Article
- Acute pharmacological profile of 2C-B-Fly-NBOMe in male Wistar rats-pharmacokinetics, effects on behaviour and thermoregulation.Frontiers in pharmacology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Gavin P SchmitzDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Yi-Ting ChiuDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-7257-7755
Mia L FoglesongDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Sarah N MageeDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Martin MacKinnonCenter for Animal MRI, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Gabriele M KönigInstitute of Pharmaceutical Biology, University of Bonn, Bonn, Germany.
Evi KostenisMolecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Bonn, Germany.
Li-Ming HsuCenter for Animal MRI, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Yen-Yu I ShihCenter for Animal MRI, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Bryan L RothDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-0561-6520
Melissa A HermanDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. melissa_herman@unc.edu.ORCID http://orcid.org/0000-0002-7260-3439
Funding
UNC ARC Information/Dissemination CoreP60AA011605 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash · 2003 to 2026
$46.3MMolecular Details of Psychoactive Drug ActionsR01MH112205 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bryan L. Roth, Brian K Shoichet · 2017 to 2026
$6.1MMechanistic insights into LSD actions at 5-HT2A serotonin receptorsR37DA045657 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bryan L. Roth · 2018 to 2026
$5.8MMOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISMP50AA011605 · NIAAA · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI CREWS, FULTON T · 1998 to 2002
$4.9MUNC Medical Scientist Training ProgramT32GM152316 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Toni Darville, Mohanish P Deshmukh · 2024 to 2026
$4.3MCircuit Mechanisms Governing the Default Mode NetworkR01MH126518 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Vinod Menon, Yen-Yu Ian Shih · 2021 to 2026
$4.3MSORDINO-fMRI for mouse brain applicationsR01EB033790 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Yen-Yu Ian Shih · 2023 to 2026
$2.5M9.4T Small Animal MRI scanner at UNCS10OD026796 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2020 to 2020
$2.0MThe role of a nucleus tractus solitarius-central amygdala circuit in alcohol-induced plasticity and drinking behaviorR01AA026858 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HERMAN, MELISSA A · 2019 to 2023
$1.7MAVANCE NEO upgrade for the BioSpec 9.4T/30cm MRI system at UNCS10MH124745 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2020 to 2020
$600kConcurrent high resolution calcium imaging and fMRI reveal intra anterior cingulate cortex neuronal activity and large-scale brain network connectivity in healthy and nicotine-addicted miceR21DA057503 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HSU, LI-MING, SHIH, YEN-YU IAN · 2023 to 2024
$428kDeciphering neural origins of interhemispheric striatal resting-state functional connectivity using simultaneous chemogenetic fMRI and triple-spectral fiber photometryR21NS133913 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN, ZHANG, WEITING · 2023 to 2023
$428kBrain and Behavior Research Foundation (Brain & Behavior Research Foundation) NARSAD Young InvestigatorNIAAA NIH HHS P50 AA011605NIAAA NIH HHS P60 AA011605NIAAA NIH HHS R01 AA026858NIA NIH HHS R21 AG083589NIBIB NIH HHS R01 EB033790NIDA NIH HHS R21 DA057503NIDA NIH HHS R37 DA045657NIGMS NIH HHS T32 GM152316NIH HHS S10 OD026796NIMH NIH HHS R01 MH112205NIMH NIH HHS R01 MH126518NIMH NIH HHS S10 MH124745NINDS NIH HHS R21 NS133913United States Department of Defense | Defense Advanced Research Projects Agency (DARPA) HR00112020029U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH112205U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA011605U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA026858U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DA045657
Abstract
Psilocybin, and its active metabolite psilocin, have seen renewed interest due to studies suggesting potential therapeutic utility. 5-Hydroxytryptamine2A receptors (5-HT
Indexed as
GTP-Binding Protein alpha Subunits, Gq-G11HallucinogensNeuronsPrefrontal CortexPsilocybinReceptor, Serotonin, 5-HT2ASerotonin 5-HT2 Receptor AgonistsAnimalsGyrus CinguliMagnetic Resonance ImagingMaleRatsGTP-Binding Protein alpha Subunits, Gq-G11HallucinogensPsilocybinReceptor, Serotonin, 5-HT2ASerotonin 5-HT2 Receptor Agonists
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.