Evidence map›Paper›PMID 41052752›Full record

ArticleJournal of pediatric surgery2026

Postnatal outcomes of in utero repair of simple gastroschisis in an ovine model.

Emily Byrd, Jamie E Anderson, Juan Maria Geronimo Lopez, Su Yeon Lee, Monalisa Hassan, Chris Pivetti, Michele Persiani, Sina Vatoofy, Zoe Saenz, Steven J McElroy and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emily ByrdDepartment of Surgery, University of California Davis Medical Center, 2335 Stockton Blvd, Room 5107, Sacramento, CA, 95817, USA.
Jamie E AndersonDepartment of Surgery, University of California Davis Medical Center, 2335 Stockton Blvd, Room 5107, Sacramento, CA, 95817, USA.
Juan Maria Geronimo LopezDepartment of Surgery, University of California Davis Medical Center, 2335 Stockton Blvd, Room 5107, Sacramento, CA, 95817, USA.
Su Yeon LeeDepartment of Surgery, University of California Davis Medical Center, 2335 Stockton Blvd, Room 5107, Sacramento, CA, 95817, USA.
Monalisa HassanDepartment of Surgery, University of California Davis Medical Center, 2335 Stockton Blvd, Room 5107, Sacramento, CA, 95817, USA.
Chris PivettiDepartment of Surgery, University of California Davis Medical Center, 2335 Stockton Blvd, Room 5107, Sacramento, CA, 95817, USA.
Michele PersianiDepartment of Pediatrics, University of California Davis Medical Center, Sacramento, CA, 95817, USA.
Sina VatoofyDepartment of Surgery, University of California Davis Medical Center, 2335 Stockton Blvd, Room 5107, Sacramento, CA, 95817, USA.
Zoe SaenzDepartment of Surgery, University of California Davis Medical Center, 2335 Stockton Blvd, Room 5107, Sacramento, CA, 95817, USA.
Steven J McElroyDepartment of Pediatrics, University of California Davis Medical Center, Sacramento, CA, 95817, USA.
Geoanna M BautistaDepartment of Pediatrics, University of California Davis Medical Center, Sacramento, CA, 95817, USA. Electronic address: gmbautista@health.ucdavis.edu.
Shinjiro HiroseDepartment of Surgery, University of California Davis Medical Center, 2335 Stockton Blvd, Room 5107, Sacramento, CA, 95817, USA. Electronic address: shinjiro.hirose@seattlechildrens.org.

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
Institutional Career Development Core (KL2)KL2TR001859 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HOLMES, JAMES F. · 2016 to 2025
$10.1M
Smooth Muscle Mechanotransduction: Calcium Dynamics in the Developing GutK08DK143334 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Geoanna Marie Bautista · 2025 to 2026
$329k
NCATS NIH HHS KL2 TR001859NCATS NIH HHS UL1 TR001860NIDDK NIH HHS K08 DK143334NIDDK NIH HHS L40 DK137356
6 · The paper itself

Abstract

backgroundGastroschisis is a congenital abdominal wall defect resulting in fetal bowel evisceration, causing significant postnatal morbidity, including prolonged bowel dysmotility and increased susceptibility to life-threatening infections. This study aims to optimize an ovine model of gastroschisis by evaluating defect size to improve fetal survival and assess the impact of in utero repair (IUR) on postnatal outcomes.

methodsOvine gastroschisis defect creation was achieved with a 2 or 3 cm abdominal wall defect at gestational age (GA) 76-82 days. Fetuses underwent repair either in utero at GA 101-107 or at birth via ex utero intrapartum treatment (EXIT) at GA 139-143. Postnatal outcomes included weight gain and bowel motility. Bowel histology, qRT-PCR of intestinal cytokines, and amniotic fluid cytokine analyses were performed.

resultsInitial defect size increase (1.5-3 cm) resulted in high rates of ring dislodgement (71%) and associated complications, which significantly improved with a 2 cm defect. Six lambs survived to delivery (four IUR and two EXIT). IUR lambs demonstrated significantly higher weight gain compared to EXIT lambs (p = 0.007) and faster barium clearance (64-84 h vs. 89- >168 h). Histologic intestinal damage was reduced in IUR animals vs. EXIT. IL-6 and IL-17A expression were increased in IUR intestine, while IFN-γ was increased in EXIT bowel. Amniotic fluid cytokine analysis demonstrated variability.

conclusionsWe describe an optimized model of ovine simple gastroschisis with in utero repair. Postnatal outcomes suggest IUR may enhance bowel motility, reduce intestinal damage, and modulate inflammatory responses more effectively than EXIT repair.

Indexed as

Disease Models, AnimalGastroschisisAmniotic FluidAnimalsAnimals, NewbornCytokinesFemaleGastrointestinal MotilityPregnancySheepTreatment OutcomeWeight GainCytokinesIn utero repairovine modelSimple gastroschisis model

Identifiers

PMID41052752
PMCPMC12706736

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.