Evidence map›Paper›PMID 41052718›Full record

ReviewJournal of advanced research2026

Role of capsaicin, circadian clock genes, and TRPV1 in colorectal carcinogenesis: Lessons and future directions.

Qiuyan Zhang, Yujia Lu, Yuchen Zhao, Chi-Tang Ho, Yuhao Zhang, Yu Fu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qiuyan ZhangCollege of Food Science, Southwest University, Chongqing 400715, China.
Yujia LuDepartment of Epidemiology, Harvard University T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.
Yuchen ZhaoDepartment of Epidemiology, Harvard University T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.
Chi-Tang HoDepartment of Food Science, Rutgers University, New Brunswick, NJ 08901, USA.
Yuhao ZhangCollege of Food Science, Southwest University, Chongqing 400715, China.
Yu FuCollege of Food Science, Southwest University, Chongqing 400715, China. Electronic address: fuy987@swu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disruptions in rhythm-regulating genes, termed circadian misalignment, have been increasingly associated with the progression of colorectal cancer (CRC), a significant global health challenge. Capsaicin (CAP), a bioactive compound found in chili pepper, has emerged as a promising modulator of clock genes, exhibiting anti-CRC potential. We propose a previously unrecognized dual-pathway mechanism where CAP may modulate circadian clock genes via both transient receptor potential vanilloid 1 (TRPV1)-dependent and TRPV1-independent pathways to inhibit colorectal carcinogenesis. Although the role of CAP in CRC prevention via clock gene regulation is compelling, direct mechanistic evidence remains limited. This paper also identifies several research gaps to underscore the necessity for further research to unlock its therapeutic potential and develop novel preventive strategies.

Indexed as

CapsaicinCarcinogenesisCircadian ClocksColorectal NeoplasmsTRPV Cation ChannelsAnimalsGene Expression Regulation, NeoplasticHumansCapsaicinTRPV1 protein, humanTRPV Cation ChannelsCapsaicinChili pepperCircadian clockColorectal cancerTRPV1

Identifiers

PMID41052718
PMCPMC13316363

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.