Evidence map›Paper›PMID 41052344›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

A time-gated PKA-CREB signaling circuit licenses IL-12 responsiveness and Th1 fate in CD4

Jingyao Zhao, Teruki Dainichi, Vincent Guichard, Yingyu Zhang, Simon Shirley, Felipe Batista Leão, Ruxiao Tian, Yuefeng Huang, Sankar Ghosh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Cord blood DNA methylation as a potential mediator in the association between prenatal ambient air pollution and early infant allergic symptoms in a Shanghai birth cohort.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
  2. Article
  3. Review
  4. Protein kinase A fuels positive feedback loops during Th1 cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. A time-gated PKA-CREB signaling circuit licenses IL-12 responsiveness and Th1 fate in CD4Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jingyao ZhaoDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Teruki DainichiDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Vincent GuichardDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Yingyu ZhangDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Simon ShirleyDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Felipe Batista LeãoDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Ruxiao TianDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Yuefeng HuangDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Sankar GhoshDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.ORCID 0000-0002-3227-0588

Funding

Understanding the role of NF-kB in T-regulatory cell functionR01AI068977 · NIAID · YALE UNIVERSITY · PI GHOSH, SANKAR · 2006 to 2017
$3.9M
Elucidation of the regulation and function of innate lymphoid cellsR35GM138805 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUANG, YUEFENG · 2020 to 2024
$2.1M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI068977HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM138805NIGMS NIH HHS R35 GM138805
6 · The paper itself

Abstract

Naïve CD4

Indexed as

CD4-Positive T-LymphocytesCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinInterleukin-12Signal TransductionTh1 CellsAnimalsCell DifferentiationInterferon-gammaLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-CellReceptors, Interleukin-12STAT4 Transcription FactorCreb1 protein, mouseCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinInterferon-gammaInterleukin-12Receptors, Antigen, T-CellReceptors, Interleukin-12Stat4 protein, mouseSTAT4 Transcription FactorGPCR-cAMP pathwayIL-12 signalingprotein kinase A (PKA)Th1 differentiation

Identifiers

PMID41052344
PMCPMC12541411

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.