Evidence map›Paper›PMID 41052342›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Single-cell lysis patterns morphogenesis of eDNA in the matrix of

Georgia R Squyres, Dianne K Newman

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Temperate phages limit their own propagation under spatial constraint in biofilms on chitin.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Extracellular matrix chemistry tunes bacterial biofilm metabolism and optimizes fitness.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Georgia R SquyresDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-8717-2897
Dianne K NewmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0003-1647-1918

Funding

Biological mechanisms and consequences of efficient extracellular electron transfer in Pseudomonas aeruginosaR01AI127850 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Dianne K Newman · 2017 to 2026
$5.6M
Damon Runyon Cancer Research Foundation (DRCRF) DRG 2439-21HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 2R01AI127850-06A1NIAID NIH HHS R01 AI127850
6 · The paper itself

Abstract

When bacteria form a biofilm, complex behaviors emerge. Biofilm bacteria differ from their free-living counterparts, exhibiting heterogenous, spatiotemporally patterned behavior. Can we explain these patterns by defining the rules that govern single-cell behavior in biofilms? By understanding these rules, can we explain emergent functions at the biofilm scale? Here we reveal how the architecture of extracellular DNA (eDNA) in the biofilm matrix is controlled by single-cell lysis during

Indexed as

BiofilmsDNA, BacterialPseudomonas aeruginosaSingle-Cell AnalysisDNA, BacterialbiofilmeDNAextracellular matrixpatterningself-organization

Identifiers

PMID41052342
PMCPMC12541396

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.