ArticleJournal of visualized experiments : JoVE2025
Modeling Dysplastic and Functional Lung Alveolar Repair after Influenza Infection.
Article in Journal of visualized experiments : JoVE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Viral infection causes both acute and long-term damage to the lung alveolus, the specialized tissue structure responsible for gas exchange between the cardiovascular system and the external environment. Influenza A virus (IAV) infection in mice represents a translational model for the response of the human lung to viral infection and induces both transient and persistent cell state changes in the alveolus. In some cases, aberrant cell states induced by viral injury that are not resolved over time may permanently impair the critical gas exchange function of the lung. This article demonstrates methods for intranasal infection of mice with A/PR/8/34 IAV and characterization of transient and long-lasting alterations to the cellular composition and tissue structure of damaged lungs. This model enables a detailed investigation into the molecular and cellular mechanisms underlying lung repair and chronic dysfunction. This approach also offers a platform for evaluating therapeutic interventions aimed at promoting effective lung regeneration and restoring respiratory function after viral injury.
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