Evidence map›Paper›PMID 41051952›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2025

Hepatic protein kinase Cβ antagonizing p38

Yaoling Shu, Amit Rai, Gina M Sizemore, Michael Ostrowski, Wei Huang, Kamal D Mehta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yaoling ShuDepartment of Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.
Amit RaiDepartment of Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.
Gina M SizemoreDepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.
Michael OstrowskiDepartment of Biochemistry and Molecular Biology, Holling Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States.
Wei HuangDepartment of Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.ORCID 0000-0002-1775-6512
Kamal D MehtaDepartment of Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.ORCID 0000-0001-8553-480X

Funding

Kruppel-like factor 11 (KLF11) and atherosclerosisR01HL138139 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHANG, JIFENG · 2017 to 2021
$2.3M
PKCbeta mediates dietary fat/cholesterol-induced cholesterol homeostasisR01HL138198 · NHLBI · OHIO STATE UNIVERSITY · PI MEHTA, KAMAL D · 2017 to 2020
$1.6M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL138198NHLBI NIH HHS R01 HL138139NHLBI NIH HHS R01 HL138198Ohio State University (OSU)
6 · The paper itself

Abstract

Lithogenic diet exposure disrupts biliary lipid homeostasis to promote precipitation of excess biliary cholesterol; however, the underlying pathogenic signaling mechanism remains unclear. Protein kinase Cbeta (PKCβ) is involved in regulating hepatic cholesterol and bile acid metabolism. In this study, we aimed to identify the initiating signaling and biological changes in the liver upon loss of hepatic PKCβ function under lithogenic stress. Transcriptome analysis of the liver revealed that hepatic deletion of PKCβ altered the expression of 183 liver genes, 118 of which were upregulated and 65 were downregulated. We identified marked increases in the expression of genes involved in bile acid biosynthesis (

Indexed as

CholelithiasisLiverMAP Kinase Signaling SystemProtein Kinase C betaAnimalsBile Acids and SaltsBiliary TractCholesterolDisease Models, AnimalGene Expression RegulationLipid MetabolismMaleMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 1Bile Acids and SaltsCholesterolMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3p38 Mitogen-Activated Protein KinasesProtein Kinase C betabile acid homeostasislithogenic dietsignal transduction

Identifiers

PMID41051952
PMCPMC12766647

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.