Evidence map›Paper›PMID 41051948›Full record

ArticleAmerican journal of physiology. Cell physiology2025

Zinc inhibits cAMP-induced Cl

Pattareeya Yottasan, Tifany Chu, Qi Gao, Parth Chhetri, Sadik Taskin Tas, Onur Cil

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pattareeya YottasanDepartment of Pediatrics, University of California, San Francisco, California, United States.
Tifany ChuDepartment of Pediatrics, University of California, San Francisco, California, United States.
Qi GaoDepartment of Pediatrics, University of California, San Francisco, California, United States.
Parth ChhetriDepartment of Pediatrics, University of California, San Francisco, California, United States.
Sadik Taskin TasDepartment of Pediatrics, University of California, San Francisco, California, United States.
Onur CilDepartment of Pediatrics, University of California, San Francisco, California, United States.ORCID 0000-0001-5178-0199

Funding

SLC26A3 (DRA) Inhibitors for Treatment of Hyperoxaluria and NephrolithiasisR01DK126070 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CIL, ONUR · 2020 to 2024
$1.6M
Roles of CaSR in ocular surface health and diseaseR01EY036139 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Onur Cil · 2024 to 2026
$1.2M
Cystic Fibrosis Foundation (CFF) CIL24G0HHS | NIH | National Eye Institute (NEI) EY036139HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK126070NEI NIH HHS R01 EY036139NIDDK NIH HHS R01 DK126070
6 · The paper itself

Abstract

Zinc is a commonly used antidiarrheal supplement; however, its exact mechanism of action is not well understood. Calcium-sensing receptor (CaSR) is a regulator of intestinal ion transport and a therapeutic target for secretory diarrhea. CaSR is activated by various cations and here we investigated the roles of CaSR in the antidiarrheal effects of the divalent metal zinc (Zn

Indexed as

AntidiarrhealsChloridesCyclic AMPEpithelial CellsIntestinal MucosaReceptors, Calcium-SensingZincAnimalsCalciumCell LineColforsinCystic Fibrosis Transmembrane Conductance RegulatorHumansMaleMiceMice, Inbred C57BLAntidiarrhealsCalciumCASR protein, humanCASR protein, mouseChloridesColforsinCyclic AMPCystic Fibrosis Transmembrane Conductance RegulatorReceptors, Calcium-SensingZincCFTRcholeraion transportsecretory diarrhea

Identifiers

PMID41051948
PMCPMC12557977

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.