Evidence map›Paper›PMID 41051937›Full record

ArticleJournal of neurotrauma2026

Acute Administration of Ampakine CX1739 after Cervical Spinal Cord Injury.

Anna F Fusco, Sabhya Rana, Maya M Macintyre, Isabelle A Gonzalez, Roberto A Ribas, Ramon C Sun, David D Fuller

Abstract read
In one paragraph

Article in Journal of neurotrauma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna F FuscoNeuroscience PhD Program, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-4245-8290
Sabhya RanaNeuroscience Department, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-1303-6614
Maya M MacintyrePhysical Therapy Department, University of Florida, Gainesville, Florida, USA.
Isabelle A GonzalezPhysical Therapy Department, University of Florida, Gainesville, Florida, USA.
Roberto A RibasBreathing Research and Therapeutics Center, University of Florida, Gainesville, Florida, USA.
Ramon C SunPhysical Therapy Department, University of Florida, Gainesville, Florida, USA.
David D FullerPhysical Therapy Department, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-5013-5972

Funding

Brain Glucose Deficiency: Mechanisms and ModulationRM1NS133593 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Joseph J. Pancrazio, Juan M. Pascual · 2023 to 2026
$5.3M
Training In Rehabilitation and Neuromuscular PlasticityT32HD043730 · NICHD · UNIVERSITY OF FLORIDA · PI DAVID D FULLER · 2003 to 2026
$5.3M
Deciphering the Glycan Code in Human Alzheimer’s Disease BrainR01AG078702 · NIA · UNIVERSITY OF KENTUCKY · PI Peggi M Angel, Sean Curtis Bendall · 2022 to 2026
$3.8M
Aberrant Glycogen in Lung Adenocarcinoma TumorigenesisR01CA266004 · NCI · UNIVERSITY OF KENTUCKY · PI Matthew S. Gentry, Ramon C. Sun · 2022 to 2026
$2.6M
Aberrant Glycogen Modulates Cerebral Glucose Metabolism in Aging and Alzheimer's DiseaseR01AG066653 · NIA · UNIVERSITY OF KENTUCKY · PI SUN, RAMON C. · 2020 to 2024
$1.9M
Normobaric Oxygen Therapy for Spinal Cord InjuryR01NS139422 · NINDS · UNIVERSITY OF FLORIDA · PI PRODIP K. BOSE, DAVID D FULLER · 2024 to 2026
$1.8M
Ampakines and Respiratory NeuroplasticityR01HL139708 · NHLBI · UNIVERSITY OF FLORIDA · PI FULLER, DAVID D · 2018 to 2021
$1.5M
Spinal Direct Current Stimulation to Enhance Breathing Following Cervical Spinal Cord InjuryK99NS133388 · NINDS · UNIVERSITY OF FLORIDA · PI RANA, SABHYA · 2024 to 2025
$253k
NCI NIH HHS R01 CA266004NHLBI NIH HHS R01 HL139708NIA NIH HHS R01 AG066653NIA NIH HHS R01 AG078702NICHD NIH HHS T32 HD043730NINDS NIH HHS K99 NS133388NINDS NIH HHS R01 NS139422NINDS NIH HHS RM1 NS133593
6 · The paper itself

Abstract

Treatment with a positive allosteric AMPA receptor modulator ("ampakine") can improve respiratory muscle activation and bladder function after sub-acute (days) to chronic (weeks to months) spinal cord injury (SCI). Prior studies of SCI and excitotoxicity provide evidence that ampakines may also promote neuroprotection. We hypothesized that initiating daily low-dose treatment with the low-impact ampakine CX1739 acutely after SCI would be neuroprotective and promote recovery. Adult rats received unilateral 150 kydne C4 contusion; CX1739 (5 mg/kg,

Indexed as

Cervical CordNeuroprotective AgentsSpinal Cord InjuriesAnimalsCervical VertebraeFemaleMaleRatsRats, Sprague-DawleyReceptors, AMPARecovery of FunctionNeuroprotective AgentsReceptors, AMPAAMPAampakineexcitotoxicityglutamateneuroprotectionspinal cord injury

Identifiers

PMID41051937
PMCPMC13535557

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.