Trial reportPsychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors2025
Standardized research electronic cigarette acceptability among adult men and women who smoke combustible cigarettes.
Trial report in Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveThe U.S. electronic cigarette marketplace is diverse and has evolved rapidly. To provide a standardized research model, the U.S. National Institute on Drug Abuse developed the Standard Research E-Cigarette (SREC). This study characterized potential gender differences in product use, acceptability, reinforcement, and nicotine dependence symptoms when switching from combustible cigarettes (CCs) to nicotine and placebo SRECs.
methodIn total, 169 adults (82 women) who smoke were enrolled in this all-remote randomized double-blind crossover trial. During Weeks 1-2, participants used their usual brand cigarettes (UBCs). During Weeks 3-4 and 5-6, they were instructed to use the tobacco-flavored SREC (either nicotine [SREC-NIC] or placebo [SREC-PLA]) in a counterbalanced order between subjects whenever they had the urge to smoke.
resultsParticipants reported smoking fewer CCs during the SREC phases compared to the UBC phase, but this did not differ between the SREC-NIC and SREC-PLA phases. The levels of urine nicotine and its metabolites were similar between the SREC-NIC and UBC phases but lower during the SRE-PLA phase. The SREC products were perceived as being less risky and were associated with a reduction in cigarette dependence and the reinforcing value of CCs. Daily measures of symptoms indicated that the SREC-PLA led to greater withdrawal and craving than the UBCs. None of these findings differed by gender.
conclusionsThese findings suggest that both adult men and women who smoke show similar responses to the National Institute on Drug Abuse SRECs in terms of product switching behavior and human abuse potential. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.